Treatment of Primary Angiitis of the Central Nervous System.
CNS vasculitis
Cyclophosphamide
Primary angiitis
Journal
Neuroimaging clinics of North America
ISSN: 1557-9867
Titre abrégé: Neuroimaging Clin N Am
Pays: United States
ID NLM: 9211377
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
medline:
13
11
2023
pubmed:
12
11
2023
entrez:
11
11
2023
Statut:
ppublish
Résumé
Primary central nervous system vasculitis (PCNSV) is a vasculitis limited to the brain and spinal cord. Induction therapy often consists of steroids and cyclophosphamide. Maintenance therapy includes a prednisone taper and may be combined with medications such as azathioprine or mycophenolate mofetil. Relapse is common in PCNSV and an increased dose of steroids is often given, sometimes with a change in therapy. Medications such as rituximab and mycophenolate mofetil may be good alternatives in those who do not respond to initial treatment or who have relapse of disease. Mortality rates of 8% to 9% are reported in the literature.
Identifiants
pubmed: 37951702
pii: S1052-5149(23)00072-2
doi: 10.1016/j.nic.2023.07.008
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Mycophenolic Acid
HU9DX48N0T
Steroids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-29Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.