The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair.
Biomaterial
Drug delivery
Elastin-like polypeptide
Tissue repair
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
11 Nov 2023
11 Nov 2023
Historique:
received:
29
03
2023
accepted:
02
11
2023
medline:
13
11
2023
pubmed:
12
11
2023
entrez:
11
11
2023
Statut:
epublish
Résumé
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials. Through genetic engineering, biomaterials prepared from ELPs can have unique and customizable properties. By adjusting the amino acid sequence and length of ELPs, nanostructures, such as micelles and nanofibers, can be formed. Correspondingly, ELPs have been used for improving the stability and prolonging drug-release time. Furthermore, ELPs have widespread use in tissue repair due to their biocompatibility and biodegradability. Here, this review summarizes the basic property composition of ELPs and the methods for modulating their phase transition properties, discusses the application of drug delivery system and tissue repair and clarifies the current challenges and future directions of ELPs in applications.
Identifiants
pubmed: 37951928
doi: 10.1186/s12951-023-02184-8
pii: 10.1186/s12951-023-02184-8
pmc: PMC10638729
doi:
Substances chimiques
Elastin
9007-58-3
Peptides
0
Biocompatible Materials
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
418Subventions
Organisme : National Natural Science Foundation of China
ID : 22276102
Organisme : Young Taishan Scholar Program of Shandong Province of China
ID : tsqn202211212
Organisme : the University Institute Innovation Team of Jinan
ID : 202228027
Organisme : Shandong Provincial Natural Science Foundation
ID : ZR2023JQ004, ZR2022MB024
Organisme : Science, Education and Industry Integration Pilot Project Plan of Qilu University of Technology (Shandong Academy of Sciences)
ID : 2023PYI002, 2022PT114
Informations de copyright
© 2023. The Author(s).
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