Neuroblastoma Patients' Outcome and Chromosomal Instability.
aneuploidy
breakpoint instability index
chromosome instability
neuroblastoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
received:
07
09
2023
revised:
20
10
2023
accepted:
21
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Chromosomal instability (CIN) induces a high rate of losses or gains of whole chromosomes or parts of chromosomes. It is a hallmark of most human cancers and one of the causes of aneuploidy and intra-tumor heterogeneity. The present study aimed to evaluate the potential prognostic role of CIN in NB patients at diagnosis. We performed array comparative genomic hybridization analyses on 451 primary NB patients at the onset of the disease. To assess global chromosomal instability with high precision, we focused on the total number of DNA breakpoints of gains or losses of chromosome arms. For each tumor, an array-CGH-based breakpoint instability index (BPI) was assigned which defined the total number of chromosomal breakpoints per genome. This approach allowed us to quantify CIN related to whole genome disruption in all NB cases analyzed. We found differences in chromosomal breakages among the NB clinical risk groups. High BPI values are negatively associated with survival of NB patients. This association remains significant when correcting for stage, age, and
Identifiants
pubmed: 37958497
pii: ijms242115514
doi: 10.3390/ijms242115514
pmc: PMC10648898
pii:
doi:
Substances chimiques
N-Myc Proto-Oncogene Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Compagnia San Paolo
ID : ID ROL 20207
Organisme : Italian Ministry of Health, RICERCA CORRENTE 2023
ID : MSALRC23
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