In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907.
5-HT2A receptor
C-11 MDL100907
aggression
positron emission tomography
serotonin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Oct 2023
28 Oct 2023
Historique:
received:
12
10
2023
revised:
26
10
2023
accepted:
26
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Serotonergic neurotransmission has been associated with aggression in several psychiatric disorders. Human aggression is a continuum of traits, ranging from normal to pathological phenomena. However, the individual differences in serotonergic neurotransmission and their relationships with aggression traits in healthy individuals remain unclear. In this study, we explored the relationship between 5-HT2A receptor availability in vivo and aggression traits in healthy participants. Thirty-three healthy participants underwent 3-Tesla magnetic resonance imaging and positron emission tomography (PET) with [
Identifiants
pubmed: 37958691
pii: ijms242115697
doi: 10.3390/ijms242115697
pmc: PMC10647245
pii:
doi:
Substances chimiques
Carbon Radioisotopes
0
Carbon-11
0
Receptor, Serotonin, 5-HT2A
0
Serotonin
333DO1RDJY
HTR2A protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT)
ID : NRF-2022R1A2C2009580 and NRF-2020R1A4A1019623
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