Cholinergic Polarization of Human Macrophages.
CHRFAM7A
acetylcholine receptor
alpha 7 nicotinic acetylcholine receptor
cholinergic
cholinergic agonist
cholinergic anti-inflammatory response
cholinergic receptor
inflammation
macrophage
polarization
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2023
29 Oct 2023
Historique:
received:
24
09
2023
revised:
20
10
2023
accepted:
23
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with the α7-nAChR being extensively studied due to its involvement in activating the cholinergic anti-inflammatory pathway. Activation of this pathway plays a crucial role in suppressing macrophages' production of proinflammatory cytokines, thus mitigating excessive inflammation and maintaining host homeostasis. Macrophage polarization, which occurs in response to specific pathogens or insults, is a process that has received limited attention concerning the activation of the cholinergic anti-inflammatory pathway and the contributions of the α7-nAChR in this context. This review aims to present evidence highlighting how the cholinergic constituents in macrophages, led by the α7-nAChR, facilitate the polarization of macrophages towards anti-inflammatory phenotypes. Additionally, we explore the influence of viral infections on macrophage inflammatory phenotypes, taking into account cholinergic mechanisms. We also review the current understanding of macrophage polarization in response to these infections. Finally, we provide insights into the relatively unexplored partial duplication of the α7-nAChR, known as dup α7, which is emerging as a significant factor in macrophage polarization and inflammation scenarios.
Identifiants
pubmed: 37958716
pii: ijms242115732
doi: 10.3390/ijms242115732
pmc: PMC10650439
pii:
doi:
Substances chimiques
alpha7 Nicotinic Acetylcholine Receptor
0
Cholinergic Agents
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103642
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM061151
Pays : United States
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