Multi-Scale Imaging of the Dynamic Organization of Chromatin.
DNA repair
chromatin organization and dynamics
high resolution imaging
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Nov 2023
04 Nov 2023
Historique:
received:
19
09
2023
revised:
27
10
2023
accepted:
27
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Chromatin is now regarded as a heterogeneous and dynamic structure occupying a non-random position within the cell nucleus, where it plays a key role in regulating various functions of the genome. This current view of chromatin has emerged thanks to high spatiotemporal resolution imaging, among other new technologies developed in the last decade. In addition to challenging early assumptions of chromatin being regular and static, high spatiotemporal resolution imaging made it possible to visualize and characterize different chromatin structures such as clutches, domains and compartments. More specifically, super-resolution microscopy facilitates the study of different cellular processes at a nucleosome scale, providing a multi-scale view of chromatin behavior within the nucleus in different environments. In this review, we describe recent imaging techniques to study the dynamic organization of chromatin at high spatiotemporal resolution. We also discuss recent findings, elucidated by these techniques, on the chromatin landscape during different cellular processes, with an emphasis on the DNA damage response.
Identifiants
pubmed: 37958958
pii: ijms242115975
doi: 10.3390/ijms242115975
pmc: PMC10649806
pii:
doi:
Substances chimiques
Chromatin
0
Nucleosomes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-22-CE12-0039-03
Organisme : Inserm
ID : ATIP AVENIR 2021
Organisme : Sorbonne University
ID : programme iBio Initiative
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