Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial.
6-MSITC
Hexaraphane
isothiocyanate
memory function
nutrition intervention
wasabi
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
12
10
2023
revised:
26
10
2023
accepted:
28
10
2023
medline:
15
11
2023
pubmed:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Cognitive functions decline with age. Declined cognitive functions negatively affect daily behaviors. Previous studies showed the positive effect of spices and herbs on cognition. In this study, we investigated the positive impact of wasabi, which is a traditional Japanese spice, on cognitive functions. The main bioactive compound of wasabi is 6-MSITC (6 methylsulfinyl hexyl isothiocyanate), which has anti-oxidant and anti-inflammatory functions. Anti-oxidants and anti-inflammatories have an important role in cognitive health. Therefore, 6-MSITC is expected to have positive effects on cognitive function. Previous studies showed the beneficial effects on cognitive functions in middle-aged adults. However, it is unclear that 6-MSITC has a positive effect on cognitive functions in healthy older adults aged 60 years and over. Here, we investigated whether 12 weeks' 6-MSITC intervention enhances cognitive performance in older adults using a double-blinded randomized controlled trial (RCT). Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a supplement (6-MSITC or a placebo) for 12 weeks. We checked a wide range of cognitive performances (e.g., executive function, episodic memory, processing speed, working memory, and attention) at the pre- and post-intervention periods. The 6-MSITC group showed a significant improvement in working and episodic memory performances compared to the placebo group. However, we did not find any significant improvements in other cognitive domains. This study firstly demonstrates scientific evidence that 6-MSITC may enhance working memory and episodic memory in older adults. We discuss the potential mechanism for improving cognitive functions after 6-MSITC intake.
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive functions decline with age. Declined cognitive functions negatively affect daily behaviors. Previous studies showed the positive effect of spices and herbs on cognition. In this study, we investigated the positive impact of wasabi, which is a traditional Japanese spice, on cognitive functions. The main bioactive compound of wasabi is 6-MSITC (6 methylsulfinyl hexyl isothiocyanate), which has anti-oxidant and anti-inflammatory functions. Anti-oxidants and anti-inflammatories have an important role in cognitive health. Therefore, 6-MSITC is expected to have positive effects on cognitive function. Previous studies showed the beneficial effects on cognitive functions in middle-aged adults. However, it is unclear that 6-MSITC has a positive effect on cognitive functions in healthy older adults aged 60 years and over. Here, we investigated whether 12 weeks' 6-MSITC intervention enhances cognitive performance in older adults using a double-blinded randomized controlled trial (RCT).
METHODS
METHODS
Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a supplement (6-MSITC or a placebo) for 12 weeks. We checked a wide range of cognitive performances (e.g., executive function, episodic memory, processing speed, working memory, and attention) at the pre- and post-intervention periods.
RESULTS
RESULTS
The 6-MSITC group showed a significant improvement in working and episodic memory performances compared to the placebo group. However, we did not find any significant improvements in other cognitive domains.
DISCUSSION
CONCLUSIONS
This study firstly demonstrates scientific evidence that 6-MSITC may enhance working memory and episodic memory in older adults. We discuss the potential mechanism for improving cognitive functions after 6-MSITC intake.
Identifiants
pubmed: 37960261
pii: nu15214608
doi: 10.3390/nu15214608
pmc: PMC10648564
pii:
doi:
Substances chimiques
Isothiocyanates
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19H01760, 22H01088
Organisme : KINJIRUSHI CO. Ltd
ID : Research grant
Références
J Tradit Complement Med. 2018 Apr 30;9(2):98-105
pubmed: 30963044
Neurology. 2000 Dec 12;55(11):1621-6
pubmed: 11113214
Biopsychosoc Med. 2023 Aug 23;17(1):30
pubmed: 37612759
Nutrients. 2020 Feb 27;12(3):
pubmed: 32120794
Cent Nerv Syst Agents Med Chem. 2013 Mar;13(1):13-29
pubmed: 23092406
Nutrients. 2018 May 23;10(6):
pubmed: 29882843
Phytochemistry. 2003 Mar;62(5):733-9
pubmed: 12620325
Psychiatry Clin Neurosci. 2006 Jun;60(3):332-9
pubmed: 16732750
Health Promot Perspect. 2018 Jan 07;8(1):33-40
pubmed: 29423360
Geroscience. 2022 Jun;44(3):1373-1392
pubmed: 35486344
J Neurosci Nurs. 2012 Aug;44(4):206-17
pubmed: 22743812
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Arch Neurol. 1991 Jan;48(1):61-4
pubmed: 1986728
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Neurol Neurosurg Psychiatry. 2023 Apr;94(4):321-325
pubmed: 36600580
J Gerontol A Biol Sci Med Sci. 2001 Oct;56(10):M638-43
pubmed: 11584037
Behav Brain Res. 2013 Oct 1;254:34-44
pubmed: 23721964
J Clin Psychol. 1997 Nov;53(7):687-97
pubmed: 9356898
Nutr Rev. 2001 Aug;59(8 Pt 2):S75-80; discussion S80-2
pubmed: 11519672
Nat Neurosci. 2014 Dec;17(12):1798-803
pubmed: 25344629
J Nutr Sci Vitaminol (Tokyo). 2012;58(4):303-7
pubmed: 23132316
Evid Based Complement Alternat Med. 2010 Dec;7(4):459-64
pubmed: 18955343
Brain Cogn. 1995 Jun;28(1):39-58
pubmed: 7546667
Int J Prev Med. 2017 Feb 07;8:5
pubmed: 28250905
J AOAC Int. 2019 Mar 1;102(2):395-411
pubmed: 30651162
Ann Neurol. 2020 Jun;87(6):816-829
pubmed: 32144793
Exp Aging Res. 1990 Autumn;16(3):155-8
pubmed: 2090468
Front Aging Neurosci. 2022 Jul 29;14:929628
pubmed: 35966784
Clin Gerontol. 2017 Jul-Sep;40(4):233-240
pubmed: 28452641
Nutrients. 2021 Jan 25;13(2):
pubmed: 33503851
J Neuroinflammation. 2018 Jan 16;15(1):17
pubmed: 29338747
J Alzheimers Dis. 2018;64(s1):S229-S254
pubmed: 29865058
Appl Physiol Nutr Metab. 2017 Jul;42(7):773-779
pubmed: 28249119
Curr Nutr Rep. 2018 Sep;7(3):139-149
pubmed: 29974344
Biopsychosoc Med. 2022 Dec 12;16(1):26
pubmed: 36510244
Front Aging Neurosci. 2019 May 07;11:99
pubmed: 31133842
Psychol Aging. 2016 Mar;31(2):166-75
pubmed: 26796792