Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the Study of Muscle, Mobility and Aging (SOMMA).
Autophagy
aging
gene expression
mTor
mitochondria
mobility
oxidative metabolism
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
05 Nov 2023
05 Nov 2023
Historique:
pubmed:
14
11
2023
medline:
14
11
2023
entrez:
14
11
2023
Statut:
epublish
Résumé
Autophagy is an essential component of proteostasis and a key pathway in aging. Identifying associations between autophagy gene expression patterns in skeletal muscle and physical performance outcomes would further our knowledge of mechanisms related with proteostasis and healthy aging. Muscle biopsies were obtained from participants in the Study of Muscle, Mobility and Aging (SOMMA). For 575 participants, RNA was sequenced and expression of 281 genes related to autophagy regulation, mitophagy and mTOR/upstream pathways were determined. Associations between gene expression and outcomes including mitochondrial respiration in muscle fiber bundles (MAX OXPHOS), physical performance (VO
Identifiants
pubmed: 37961308
doi: 10.1101/2023.11.04.23297979
pmc: PMC10635272
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059416
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest statement. S.R.C. is a consultant to Bioage Labs. P.M.Ca. is a consultant to and owns stock in MyoCorps. All other authors declare no conflict of interest. A.M.C is a consultant to Generian Therapeuthics and it is a consultant to and owns stock in Life Biosciences.
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