Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires' disease.

Severe Legionnaires' disease (LD) can lead to multi-organ failure or death in 10%-30% of patients. Although hyper-inflammation and immunoparalysis are well described in sepsis and are associated with high disease severity, little is known about the immune response in LD. This study aimed to evaluate the immune status of patients with LD and its association with disease severity. A total of 92 hospitalized LD patients were included; 19 plasmatic cytokines and pulmonary Among the 84 patients, a higher secretion of plasmatic MCP-1, MIP1-β, IL-6, IL-8, IFN-γ, TNF-α, and IL-17 was observed in the patients with D0 and D8 MV. Multiparametric analysis showed that these seven cytokines were positively associated with the SOFA score. Upon conA stimulation, LD patients had a lower secretion capacity for 16 of the 19 quantified cytokines and a higher release of IL-18 and MCP-1 compared to HV. IL-18 secretion was higher in D0 and D8 MV patients. TNF-α secretion, measured after The present findings describe a hyper-inflammatory phase at the initial phase of

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Copyright © 2023 Allam, Mouton, Testaert, Ginevra, Fessy, Ibranosyan, Descours, Beraud, Guillemot, Chapalain, Albert-Vega, Richard, Argaud, Friggeri, Labeye, Jamilloux, Freymond, Venet, Lina, Doublet, Ader, Trouillet-Assant and Jarraud.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.