Enhancing Stability and Albumin Binding Efficiency of α-Conotoxin GI through Fatty Acid Modification.

Receptors, Nicotinic / chemistry Amino Acid Sequence Conotoxins / pharmacology Fatty Acids

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
05 Dec 2023
Historique:
medline: 6 12 2023
pubmed: 16 11 2023
entrez: 15 11 2023
Statut: ppublish

Résumé

α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery. In this study, four fatty acid-modified α-conotoxin GI analogues of different lengths were synthesized by using a fatty acid modification strategy. Then, we performed a series of

Identifiants

DOI: 10.1021/acs.biochem.3c00385 PMID: 37967580
pubmed: 37967580
doi: 10.1021/acs.biochem.3c00385
doi:

Substances chimiques

conotoxin GI 76862-65-2
Receptors, Nicotinic 0
Conotoxins 0
Fatty Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3373-3382

Auteurs

Panpan Qi (P)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Quankuo He (Q)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Junjie Zhang (J)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Yuanyuan Lian (Y)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Ting Xie (T)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Jianying Dong (J)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.

Dongting Zhangsun (D)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.
Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China.

Yong Wu (Y)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.
ORCID: 0000-0001-6395-4213

Sulan Luo (S)

School of Medicine, Guangxi University, Guangxi Key Laboratory of Special Biomedicine, Nanning 530004, China.
Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Enhancing Stability and Albumin Binding...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Enhancing Stability and Albumin Binding...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Enhancing Stability and Albumin Binding...
questionsmedicales.fr › Lipides › Acides gras › Enhancing Stability and Albumin Binding...