Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
received:
23
11
2022
accepted:
19
09
2023
medline:
27
11
2023
pubmed:
16
11
2023
entrez:
15
11
2023
Statut:
epublish
Résumé
Occlusal disharmony is known to affect not only the oral cavity environment, but also the autonomic nervous system in the heart. Since the renin-angiotensin system (RAS) inhibitor captopril (Cap) is one of the first-line drugs for preventing cardiac remodeling in patients with heart failure, we hypothesized that Cap might prevent cardiac dysfunction induced by occlusal disharmony. Here, to test this idea, we used our bite-opening (BO) mouse model, which was developed by cementing a suitable appliance onto the mandibular incisor. Mice were divided into four groups: (1) Control, (2) BO, (3) Cap, and (4) BO + Cap. After 2 weeks, we evaluated cardiac function by echocardiography and confirmed that cardiac function was significantly decreased in the BO group compared to the control, while Cap ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and oxidative stress-induced myocardial damage in the BO group were significantly increased versus the control, and these increases were suppressed by Cap. Cardiac dysfunction induced by BO was associated with dual phosphorylation on PKCδ (Tyr-311/Thr-505), leading to activation of CaMKII with increased phosphorylation of RyR2 and phospholamban. Our results suggest that the RAS might play an important role in the development of cardiac diseases induced by occlusal anomalies.
Identifiants
pubmed: 37968296
doi: 10.1038/s41598-023-43099-6
pii: 10.1038/s41598-023-43099-6
pmc: PMC10651878
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Captopril
9G64RSX1XD
Enzyme Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19927Subventions
Organisme : Japan Society for the Promotion of Science
ID : 21K17171
Organisme : Japan Society for the Promotion of Science
ID : 20K10304
Organisme : Japan Society for the Promotion of Science
ID : 20K10305
Organisme : Japan Society for the Promotion of Science
ID : 22K21003
Organisme : Japan Society for the Promotion of Science
ID : 22K10255
Organisme : Japan Society for the Promotion of Science
ID : 21K10242
Informations de copyright
© 2023. The Author(s).
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