Bcl-xL mediates interferon-beta secretion by protease-activated receptor 2 deficiency through the mitochondrial permeability transition pore in colorectal cancer metastasis.
Colorectal cancer
Interferon
Metastasis
Mitochondria
Permeability transition pore
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
01 Jan 2024
01 Jan 2024
Historique:
received:
05
07
2023
revised:
27
10
2023
accepted:
03
11
2023
medline:
4
12
2023
pubmed:
17
11
2023
entrez:
16
11
2023
Statut:
ppublish
Résumé
Cellular plasticity and immune escape are synergistic drivers of tumor colonization in metastatic organs. Activation of protease-activated receptor 2 (PAR2) signaling promotes metastasis of colorectal carcinoma (CRC). The role of PAR2 in regulating the immune microenvironment and cancer progression remains unclear. We demonstrated that the regulation of liver metastasis by PAR2 requires a competent immune system. PAR2 knockdown enhanced liver infiltration of activated CD8
Identifiants
pubmed: 37972702
pii: S0304-3835(23)00434-2
doi: 10.1016/j.canlet.2023.216483
pii:
doi:
Substances chimiques
Interferon-beta
77238-31-4
Mitochondrial Permeability Transition Pore
0
Receptor, PAR-2
0
BCL2L1 protein, human
0
F2RL1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
216483Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.