Host-microbe tryptophan partitioning in cardiovascular diseases.
Cardiovascular diseases
Metabolites
Microbiota
Omics
Tryptophan metabolism
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
31
07
2023
revised:
27
10
2023
accepted:
13
11
2023
medline:
5
12
2023
pubmed:
17
11
2023
entrez:
16
11
2023
Statut:
ppublish
Résumé
The functional interdependencies between the molecular components of a biological process demand for a network medicine platform that integrates systems biology and network science, to explore the interactions among biological components in health and disease. Access to large-scale omics datasets (genomics, transcriptomics, proteomics, metabolomics, metagenomics, phenomics, etc.) has significantly advanced our opportunity along this direction. Studies utilizing these techniques have begun to provide us with a deeper understanding of how the interaction between the intestinal microbes and their host affects the cardiovascular system in health and disease. Within the framework of a multiomics network approach, we highlight here how tryptophan metabolism may orchestrate the host-microbes interaction in cardiovascular diseases and the implications for precision medicine and therapeutics, including nutritional interventions.
Identifiants
pubmed: 37972721
pii: S1043-6618(23)00350-X
doi: 10.1016/j.phrs.2023.106994
pii:
doi:
Substances chimiques
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106994Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.