Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication.
COVID-19
Hop compounds
Papain-like protease
SARS-CoV-2
Viral proteases
Xanthohumol
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
04
07
2023
revised:
27
10
2023
accepted:
29
10
2023
medline:
18
11
2023
pubmed:
18
11
2023
entrez:
17
11
2023
Statut:
aheadofprint
Résumé
Selected natural compounds exhibit very good antiviral properties. Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously shown antiviral activities. Among them, the prenylated chalcone xanthohumol (XN) demonstrated to be a potent inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M Following the finding that xanthohumol (XN) is a potent inhibitor of SARS-CoV-2 M The modulatory effect of the hop compounds on PL In silico docking analysis was used to predict the binding affinity of hop compounds to the active site of PL Our in silico docking suggests that the purified hop compounds bind to the active site of SARS-CoV-2 PL In addition to the already known inhibition of M
Sections du résumé
BACKGROUND
BACKGROUND
Selected natural compounds exhibit very good antiviral properties. Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously shown antiviral activities. Among them, the prenylated chalcone xanthohumol (XN) demonstrated to be a potent inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M
HYPOTHESIS/PURPOSE
OBJECTIVE
Following the finding that xanthohumol (XN) is a potent inhibitor of SARS-CoV-2 M
STUDY DESIGN
METHODS
The modulatory effect of the hop compounds on PL
METHODS
METHODS
In silico docking analysis was used to predict the binding affinity of hop compounds to the active site of PL
RESULTS
RESULTS
Our in silico docking suggests that the purified hop compounds bind to the active site of SARS-CoV-2 PL
CONCLUSION
CONCLUSIONS
In addition to the already known inhibition of M
Identifiants
pubmed: 37976697
pii: S0944-7113(23)00535-4
doi: 10.1016/j.phymed.2023.155176
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
155176Informations de copyright
Copyright © 2023. Published by Elsevier GmbH.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The funders had no role in the collection, analysis, or interpretation of data, in writing of the manuscript, or in the decision to publish the results. The University Hospital of Tübingen is assignee for the following patents (US-9855242-B2, EP2968261A1) concerning the use of hop compounds for an immunomodulation. All authors declare that apart from the above points there are no other conflicts of interest.