Assessment of osteoprotegerin and RANKL levels and several cardiovascular risk scoring systems in acromegaly.
Acromegaly
Cardiovascular risk score
Osteoprotegerin
Receptor-activated nuclear factor kappa-B ligand
Journal
Hormones (Athens, Greece)
ISSN: 2520-8721
Titre abrégé: Hormones (Athens)
Pays: Switzerland
ID NLM: 101142469
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
19
06
2023
accepted:
09
11
2023
medline:
8
2
2024
pubmed:
20
11
2023
entrez:
19
11
2023
Statut:
ppublish
Résumé
The OPG/RANKL (osteoprotegerin/receptor activator of nuclear factor kappa-B) system, which plays a crucial role in bone metabolism, is also associated with vascular calcification. Acromegaly is characterized by excessive secretion of growth hormone and insulin-like growth factor, and studies have demonstrated an elevated risk of cardiovascular disease in individuals with acromegaly. In this study, our objective was to investigate the relationship between OPG/RANKL and various cardiovascular risk scoring systems. We recruited 44 consecutive acromegaly patients and 41 healthy controls with a similar age and gender distribution for this study. While RANKL levels were significantly higher in the acromegaly group compared to the controls, OPG levels were not found to be significantly different between the two groups. Furthermore, within the acromegaly group, RANKL levels were significantly higher in patients with active acromegaly compared to those with controlled acromegaly. Osteoprotegerin levels showed a positive correlation with the Framingham risk score (FRS) in the acromegaly group. Linear regression analysis revealed an association of OPG with FRS (adjusted R OPG and RANKL may serve as potential markers for assessment of cardiovascular calcification and prediction of the cardiovascular risk status in acromegalic patients.
Identifiants
pubmed: 37981618
doi: 10.1007/s42000-023-00509-8
pii: 10.1007/s42000-023-00509-8
doi:
Substances chimiques
Osteoprotegerin
0
Receptor Activator of Nuclear Factor-kappa B
0
RANK Ligand
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-88Informations de copyright
© 2023. The Author(s), under exclusive licence to Hellenic Endocrine Society.
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