Glandular Schwannoma With Apocrine Decapitation Secretion: A True Divergent Differentiation or Entrapped Normal Tissue?
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
medline:
21
11
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
ppublish
Résumé
We report an unusual case of schwannoma with glandular elements that demonstrated apocrine decapitation secretion. The glandular structures were embedded within the tumor, varied in shape and size, and were lined by a double-to-multilayered epithelium, with the inner layer composed of monomorphous cuboidal to columnar cells, focally with apocrine decapitation secretion, and the outer layer representing myoepithelial cells. A normal eccrine unit was observed near the lesion. Immunohistochemical studies showed that all luminal cells of the glandular structures stained positive for CK7, whereas myoepithelial cells expressed S100 and p63, and epithelial membrane antigen highlighted the luminal border. CK20 and neuroendocrine markers were negative in the glandular elements.Our findings suggest that the origin of the glandular elements in our case was represented by entrapped glands. Two theories may explain the epithelial hyperplasia observed in the present case as follows: the obstructive effect theory and the inductive ability of a mesenchymal proliferation to produce epidermal or adnexal changes. We suggest that, in a subset of cases, the origin of the glandular elements might represent entrapped glands, wherein their histomorphology/cytomorphology recapitulates the elements comprising the normal adjacent tissue. Further research is necessary to elucidate the histogenesis of glandular schwannoma.
Identifiants
pubmed: 37982466
doi: 10.1097/DAD.0000000000002568
pii: 00000372-202312000-00011
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-842Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Nascimento AF, Fletcher CD. The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol. 2007;31:1363–1370.
Dahl I. Ancient neurilemmoma (schwannoma). Acta Pathologica Microbiologica Scand Section A Pathol. 2009;85A:812–818.
Fletcher CDM, Davies SE, McKee PH. Cellular schwannoma: a distinct pseudosarcomatous entity. Histopathology. 2007;11:21–35.
Kindblom LG, Meis-Kindblom JM, Havel G, et al. Benign epithelioid schwannoma. Am J Surg Pathol. 1998;22:762–770.
Kao GF, Laskin WB, Olsen TG. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Mod Pathol. 1989;2:20–26.
Fletcher CD, Madziwa D, Heyderman E, et al. Benign dermal Schwannoma with glandular elements--true heterology or a local 'organizer' effect?. Clin Exp Dermatol. 1986;11:475–485.
Chan JK, Fok KO. Pseudoglandular schwannoma. Histopathology. 1996;29:481–484.
Ducatman B, Scheithauer B. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer. 1984;54:1049–1057.
Holliday AC, Mazloom SE, Coman GC, et al. Benign glandular schwannoma with ancient change. Am J Dermatopathol. 2017;39:300–303.
Saggini A, Di Prete M, D’Amico F, et al. Glandular schwannoma: an uncommon variant of schwannoma with controversial histogenesis. Dermatopathology (Basel). 2019;6:206–212.
Li X, Kaur H, Xu W, et al. Benign glandular schwannoma in basal Ganglia. World Neurosurg. 2017;97:762.e1–762.e4.
Bigorgne C, Thomine E, Hemet J, et al. Schwannome glandulaire bénin et maladie de Recklinghausen. A propos d'un cas [Benign glandular schwannoma and Recklinghausen disease. Report of a case]. Ann Pathol. 1992;12:114–120.
Woodruff JM. Peripheral nerve tumors showing glandular differentiation (glandular schwannomas). Cancer. 1976;37:2399–2413.
Hajdu SI. Pathology of Soft Tissue Tumors. Philadelphia, PA: Lippincott Williams and Wilkins; 1980:448–450.
Papanicolaou SJ, Eversole LR. Glandular structures in neural sheath neoplasms. Oral Surg Oral Med Oral Pathol. 1982;53:69–72.
Brooks J, Draffen R. Benign glandular schwannoma. Arch Pathol Lab Med. 1992;116:192–195.
Yoshida SO, Toot BV. Benign glandular schwannoma. Am J Clin Pathol. 1993;100:167–170.
Elston DM, Bergfeld WF, Biscotti CV, et al. Schwannoma with sweat duct differentiation. J Cutan Pathol. 1993;20:254–258.
Oda Y, Hashimoto H, Tsuneyoshi M, et al. Benign glandular peripheral nerve sheath tumor: a case report. Pathol Res Pract. 1994;190:466–473.
Kim YC, Park HJ, Cinn YW, et al. Benign glandular schwannoma. Br J Dermatol. 2001;145:834–837.
Chuang ST, Wang HL. An unusual case of glandular schwannoma. Hum Pathol. 2007;38:673–677.
Tarjan G. Schwannoma including epithelial elements mimicking pleomorphic adenoma of the submandibular gland on fine-needle cytology: the first case report: glandular schwannoma in submandibular gland. Diagn Cytopathol. 2015;43:395–398.
Garre C. Uber sekundar maligne neurome. Bietr Z Klin Chir. 1892;9:465.
Krumerman MS, Stingle W. Synchronous malignant glandular schwannomas in congenital neurofibromatosis. Cancer. 1978;41:2444–2451.
Uri AK, Witzleben CL, Raney RB. Electron microscopy of glandular Schwannoma. Cancer. 1984;53:493–497.
DeSchryver K, Santa Cruz DJ. So-called glandular schwannoma: ependymal differentiation in a case. Ultrastructural Pathol. 1984;6:167–175.
Kazakov DV, Spagnolo DV, Kacerovska D, et al. Cutaneous adenolipoma: extending the spectrum of changes in the lipomatous and epithelial components. Am J Dermatopathol. 2011;33:56–59.
Muto I, Kuwahara F, Shintani T, et al. Adenodermatofibroma possessing dilated glandular structures with eccrine features: a case study. J Cutan Pathol. 2018;45:623–628.
Tran TAN. Primary cutaneous solitary fibrous tumor with entrapped eccrine components. J Cutan Pathol. 2020;47:845–849.
Mehregan AH. Proliferation of sweat ducts in certain diseases of the skin. Am J Dermatopathol. 1981;3:27–32.
Requena L, Yus ES, Simon P, et al. Induction of cutaneous hyperplasias by altered stroma. Am J Dermatopathol. 1996;18:248–268.