A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system.
Enteric nervous system
Homozygous mutant of Ncx
Intestinal neuronal dysplasia
Sox10
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
accepted:
30
10
2023
medline:
27
11
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
epublish
Résumé
Intestinal neuronal dysplasia (IND) is a congenital anomaly affecting gastrointestinal neural innervation, but the pathogenesis remains unclear. The homozygous Ncx/Hox11L.1 knockout (Ncx Sox10-Venus Ncx This study has established a reliable animal model that exhibits characteristics similar to patients with IND. This novel mouse model can allow the easy visualization of ENS in a time- and cost-effective way to study the pathogenesis of IND.
Identifiants
pubmed: 37982893
doi: 10.1007/s00383-023-05585-w
pii: 10.1007/s00383-023-05585-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
298Subventions
Organisme : JSPS KAKENHI
ID : 22K08721
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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