Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
received:
07
07
2022
accepted:
31
10
2023
medline:
22
11
2023
pubmed:
21
11
2023
entrez:
20
11
2023
Statut:
epublish
Résumé
Neuroinflammation in the brain contributes to the pathogenesis of Parkinson's disease (PD), but the potential dysregulation of peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated peripheral cytotoxic immune milieu, with more terminally-differentiated effector memory (TEMRA) CD8 T, CD8
Identifiants
pubmed: 37985656
doi: 10.1038/s41467-023-43053-0
pii: 10.1038/s41467-023-43053-0
pmc: PMC10662447
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7461Subventions
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : CORE/14/BM/8231540/GeDES
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : Tregbar/11228353
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : PRIPRIDDE/11012546/NEXTIMMUNE
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : PRIDE/10907093/CRITICS
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : PRIDE/14254520/i2TRON
Organisme : Fonds National de la Recherche Luxembourg (National Research Fund)
ID : PHD-2015-1/9989160
Organisme : Integrated BioBank of Luxembourg (IBBL)
ID : CoPImmunoPD, PMC/2018/01
Informations de copyright
© 2023. The Author(s).
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