Prevalence of Pericardial Late Gadolinium Enhancement in Patients After Cardiac Surgery: Clinical and Histological Correlations.

Humans Contrast Media Gadolinium Prevalence Pericardium / diagnostic imaging Pericarditis Cardiac Surgical Procedures / adverse effects Inflammation Magnetic Resonance Imaging, Cine / methods Predictive Value of Tests
biopsy cardiac surgery cardiovascular magnetic resonance pericarditis prevalence

Journal

Circulation. Cardiovascular imaging
ISSN: 1942-0080
Titre abrégé: Circ Cardiovasc Imaging
Pays: United States
ID NLM: 101479935

Informations de publication

Date de publication:
Nov 2023
Historique:
medline: 27 11 2023
pubmed: 21 11 2023
entrez: 21 11 2023
Statut: ppublish

Résumé

Pericardial late gadolinium enhancement (LGE) is usually associated with active pericarditis, but it is not infrequently found in patients after cardiac surgery even a long time after the intervention. The clinical relevance of this finding and its histological correlates are unknown. We sought to determine the prevalence of chronic pericardial LGE in patients after cardiac surgery. All consecutive patients with previous cardiac surgery, who were referred to cardiovascular magnetic resonance between January 2017 and December 2021 were enrolled in the study. Cardiovascular magnetic resonance examination protocol was adapted to clinical indication but always included standard LGE acquisitions. Two independent observers blinded to clinical data assessed the presence of pericardial enhancement on LGE sequences. Fifteen patients underwent cardiac reintervention and pericardial biopsies were obtained. The primary study end point was to assess the prevalence of pericardial enhancement after cardiac surgery and identify possible determinants. The secondary end point was to correlate pericardial enhancement with clinical symptoms and histopathology. Two hundred four patients were included in the study. The median time between surgery and cardiovascular magnetic resonance was 160 months (35-226 months). Pericardial LGE was observed in 90 patients (44%). All patients were asymptomatic, and no specific treatment for pericarditis was started. All patients remained asymptomatic at a 1-year clinical follow-up. Pericardial LGE was significantly correlated with the number of previous surgeries ( Pericardial LGE is a frequent finding even several years after cardiac surgery. Its histological correlate is a chronic subclinical post-pericardiotomy inflammation.

Sections du résumé

BACKGROUND UNASSIGNED
Pericardial late gadolinium enhancement (LGE) is usually associated with active pericarditis, but it is not infrequently found in patients after cardiac surgery even a long time after the intervention. The clinical relevance of this finding and its histological correlates are unknown. We sought to determine the prevalence of chronic pericardial LGE in patients after cardiac surgery.
METHODS UNASSIGNED
All consecutive patients with previous cardiac surgery, who were referred to cardiovascular magnetic resonance between January 2017 and December 2021 were enrolled in the study. Cardiovascular magnetic resonance examination protocol was adapted to clinical indication but always included standard LGE acquisitions. Two independent observers blinded to clinical data assessed the presence of pericardial enhancement on LGE sequences. Fifteen patients underwent cardiac reintervention and pericardial biopsies were obtained. The primary study end point was to assess the prevalence of pericardial enhancement after cardiac surgery and identify possible determinants. The secondary end point was to correlate pericardial enhancement with clinical symptoms and histopathology.
RESULTS UNASSIGNED
Two hundred four patients were included in the study. The median time between surgery and cardiovascular magnetic resonance was 160 months (35-226 months). Pericardial LGE was observed in 90 patients (44%). All patients were asymptomatic, and no specific treatment for pericarditis was started. All patients remained asymptomatic at a 1-year clinical follow-up. Pericardial LGE was significantly correlated with the number of previous surgeries (
CONCLUSIONS UNASSIGNED
Pericardial LGE is a frequent finding even several years after cardiac surgery. Its histological correlate is a chronic subclinical post-pericardiotomy inflammation.

Identifiants

DOI: 10.1161/CIRCIMAGING.123.015606 PMID: 37988447
pubmed: 37988447
doi: 10.1161/CIRCIMAGING.123.015606
doi:

Substances chimiques

Contrast Media 0
Gadolinium AU0V1LM3JT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e015606

Auteurs

Anna Giulia Pavon (AG)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University hospital, Switzerland (A.G.P., D.A., J.S., P.M., T.R.).
Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland (A.G.P., L.B.).
ORCID: 0000-0002-8001-1476

Ruben Martinez Fernandez (R)

University of Lausanne (Unil), Switzerland (R.M.F., J.S., P.M., T.R.).

Dimitri Arangalage (D)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University hospital, Switzerland (A.G.P., D.A., J.S., P.M., T.R.).
ORCID: 0000-0002-0898-9090

Luca Bergamaschi (L)

Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland (A.G.P., L.B.).
ORCID: 0000-0001-8186-9717

Niccolò Maurizi (N)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
ORCID: 0000-0001-5819-204X

Sebastien Colombier (S)

Department of Cardiac Surgery, Lausanne University Hospital (CHUV), Switzerland (S.C., A.N., M.K.).
Department of Cardiac Surgery, Hôpital du Valais (HVS), Sion, Switzerland (S.C.).
ORCID: 0000-0002-0612-2311

Samuel Rotman (S)

Service of Clinical Pathology, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland (S.R.).
ORCID: 0000-0002-2508-3725

Anna Nowacka (A)

Department of Cardiac Surgery, Lausanne University Hospital (CHUV), Switzerland (S.C., A.N., M.K.).
ORCID: 0000-0001-6260-1635

Judith Bouchardy (J)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
ORCID: 0000-0003-0149-288X

Juerg Schwitter (J)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University hospital, Switzerland (A.G.P., D.A., J.S., P.M., T.R.).
University of Lausanne (Unil), Switzerland (R.M.F., J.S., P.M., T.R.).
ORCID: 0000-0002-9966-6149

Matthias Kirsch (M)

Department of Cardiac Surgery, Lausanne University Hospital (CHUV), Switzerland (S.C., A.N., M.K.).
ORCID: 0000-0002-9213-7578

Pierre Monney (P)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University hospital, Switzerland (A.G.P., D.A., J.S., P.M., T.R.).
University of Lausanne (Unil), Switzerland (R.M.F., J.S., P.M., T.R.).

Tobias Rutz (T)

Department of Cardiology, Lausanne University Hospital (CHUV), Switzerland (A.G.P., D.A., N.M., J.B., J.S., P.M., T.R.).
Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University hospital, Switzerland (A.G.P., D.A., J.S., P.M., T.R.).
University of Lausanne (Unil), Switzerland (R.M.F., J.S., P.M., T.R.).
ORCID: 0000-0001-5899-291X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Gadolinium › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Tissus › Membranes › Séreuse › Péricarde › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Péricardite › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › IRM dynamique › Prevalence of Pericardial Late Gadolinium...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Prevalence of Pericardial Late Gadolinium...