Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.
Schwann cell
adipocytes
energy metabolism
leptin
leptin receptor
metabolic adaptation
mitochondrial respiration
myelin autophagy
myelinophagy
nerve repair
oxidative phosphorylation
peripheral nerve injury
regeneration
remyelination
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
05 12 2023
05 12 2023
Historique:
received:
02
12
2022
revised:
21
08
2023
accepted:
30
10
2023
medline:
11
12
2023
pubmed:
22
11
2023
entrez:
21
11
2023
Statut:
ppublish
Résumé
The peripheral nervous system harbors a remarkable potential to regenerate after acute nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral nerve Schwann cells that orchestrate breakdown and resynthesis of myelin and, at the same time, support axonal regrowth. How Schwann cells meet the high metabolic demand required for nerve repair remains poorly understood. We here report that nerve injury induces adipocyte to glial signaling and identify the adipokine leptin as an upstream regulator of glial metabolic adaptation in regeneration. Signal integration by leptin receptors in Schwann cells ensures efficient peripheral nerve repair by adjusting injury-specific catabolic processes in regenerating nerves, including myelin autophagy and mitochondrial respiration. Our findings propose a model according to which acute nerve injury triggers a therapeutically targetable intercellular crosstalk that modulates glial metabolism to provide sufficient energy for successful nerve repair.
Identifiants
pubmed: 37989315
pii: S1550-4131(23)00386-8
doi: 10.1016/j.cmet.2023.10.017
pmc: PMC10722468
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2136-2152.e9Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : P20 GM103425
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD059056
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD087057
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM011070
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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