Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
25
05
2023
accepted:
07
11
2023
revised:
24
10
2023
medline:
23
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
epublish
Résumé
Sensory processing is the process by which the central nervous system gathers, interprets, and regulates sensory stimuli in response to environmental cues. However, our understanding of the genetic factors and neuroanatomical correlations that influence sensory processing is limited. The vasotocin system modulates sensory input responsiveness, making it a potential candidate for further investigation. Additionally, human neuroimaging studies have demonstrated that the ability to modulate sensory stimuli is related to neuroanatomical features such as cortical thickness. Therefore, this study aimed to examine the relationship between functional polymorphisms in vasotocin receptor (VTR) genes, sensory profiles, and neuroanatomical correlations. We used structural magnetic resonance imaging (MRI) and the Adolescent/Adult Sensory Profile (AASP) questionnaire in 98 healthy adult participants to assess sensory processing and identified seven single nucleotide polymorphisms. We found that A-allele carriers of rs1042615 in VTR had higher scores for "sensory sensitivity" and "sensation avoiding". Moreover, higher scores for three AASP subscales were associated with decreased cortical thickness in various regions, including the right precentral, paracentral, and fusiform gyri, as well as bilateral inferior temporal gyri. This study sheds light on the potential role of genetic variations in the VTR in modulating sensory processing and correlation with cortical thickness which has future implications for better understanding sensory abnormalities in neurodevelopmental disorders.
Identifiants
pubmed: 37990008
doi: 10.1038/s41398-023-02657-2
pii: 10.1038/s41398-023-02657-2
pmc: PMC10663457
doi:
Substances chimiques
vasotocin receptor
0
Vasotocin
W6S6URY8OF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
356Subventions
Organisme : Ministry of Science, ICT and Future Planning (MSIP)
ID : 23-BR-05-01
Organisme : Ministry of Education, Culture, Sports, Science and Technology (MEXT)
ID : 20H01766
Organisme : Ministry of Education, Culture, Sports, Science and Technology (MEXT)
ID : 20H04272
Organisme : National Research Foundation of Korea (NRF)
ID : 2022R1F1A1066114
Informations de copyright
© 2023. The Author(s).
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