Current cough and sputum assessed by the cough and sputum assessment-questionnaire (CASA-Q) is associated with quality of life impairment in cystic fibrosis.
CASA-Q
CFQ-R
Cough
Cystic fibrosis
Quality of life
Sputum
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
12
06
2023
accepted:
09
10
2023
medline:
23
11
2023
pubmed:
22
11
2023
entrez:
22
11
2023
Statut:
epublish
Résumé
Cough and sputum are major symptoms in cystic fibrosis (CF) that contribute to the impairment of quality of life. This prospective single centre cross-sectional pilot study aimed to evaluate the results of a self-administered questionnaire assessing cough and sputum symptoms (2 domains), and their impact (2 domains) on daily activities in the previous week, named the Cough and Sputum Assessment Questionnaire (CASA-Q) in CF adult patients at stable state, and to analyse associations with clinical, functional, microbiological, radiological data, and two quality of life scales: the Cystic Fibrosis Questionnaire Revised (CFQ-R) and the Saint George Respiratory Questionnaire (SGRQ). Forty-eight patients were included in this analysis (69% men; median age of 27.8 ± 8.1 years; median body mass index of 21.8 + 3.3 kg/m²; mean FEV CASA-Q allows the assessment of cough and sputum in CF adult patients and is associated with quality of life impairment. This simple easy-to-use tool could be used in routine clinical practice and in clinical studies to assess cough and sputum in CF patients. The study was registered on ClinicalTrials.gov (NCT02924818, first posted on 5th October 2016).
Sections du résumé
BACKGROUND
BACKGROUND
Cough and sputum are major symptoms in cystic fibrosis (CF) that contribute to the impairment of quality of life.
METHODS
METHODS
This prospective single centre cross-sectional pilot study aimed to evaluate the results of a self-administered questionnaire assessing cough and sputum symptoms (2 domains), and their impact (2 domains) on daily activities in the previous week, named the Cough and Sputum Assessment Questionnaire (CASA-Q) in CF adult patients at stable state, and to analyse associations with clinical, functional, microbiological, radiological data, and two quality of life scales: the Cystic Fibrosis Questionnaire Revised (CFQ-R) and the Saint George Respiratory Questionnaire (SGRQ).
RESULTS
RESULTS
Forty-eight patients were included in this analysis (69% men; median age of 27.8 ± 8.1 years; median body mass index of 21.8 + 3.3 kg/m²; mean FEV
CONCLUSIONS
CONCLUSIONS
CASA-Q allows the assessment of cough and sputum in CF adult patients and is associated with quality of life impairment. This simple easy-to-use tool could be used in routine clinical practice and in clinical studies to assess cough and sputum in CF patients.
TRIAL REGISTRATION
BACKGROUND
The study was registered on ClinicalTrials.gov (NCT02924818, first posted on 5th October 2016).
Identifiants
pubmed: 37990322
doi: 10.1186/s12890-023-02701-3
pii: 10.1186/s12890-023-02701-3
pmc: PMC10664648
doi:
Banques de données
ClinicalTrials.gov
['NCT02924818']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
457Informations de copyright
© 2023. The Author(s).
Références
Proc Am Thorac Soc. 2007 Aug 1;4(4):378-86
pubmed: 17652505
Respir Investig. 2019 May;57(3):252-259
pubmed: 30738923
J Cyst Fibros. 2003 Mar;2(1):29-34
pubmed: 15463843
Arch Bronconeumol. 2007 Apr;43(4):205-11
pubmed: 17397584
Nat Rev Genet. 2015 Jan;16(1):45-56
pubmed: 25404111
Lancet. 2009 May 30;373(9678):1891-904
pubmed: 19403164
Qual Life Res. 2003 Feb;12(1):77-85
pubmed: 12625520
Radiology. 2008 Mar;246(3):697-722
pubmed: 18195376
Health Qual Life Outcomes. 2022 Oct 6;20(1):141
pubmed: 36203159
Chest. 2005 Oct;128(4):2347-54
pubmed: 16236893
Clin Exp Allergy. 2019 Jun;49(6):781-788
pubmed: 30710420
Qual Life Res. 2012 Sep;21(7):1279-90
pubmed: 22240933
Pediatr Clin North Am. 2016 Aug;63(4):567-84
pubmed: 27469176
Open Respir Med J. 2016 Dec 30;10:105-108
pubmed: 28217196
Respir Med. 2010 Apr;104(4):534-41
pubmed: 19917525
Physiotherapy. 2020 Jun;107:243-251
pubmed: 32026826
Respir Med. 2008 Nov;102(11):1545-55
pubmed: 18662868
J Pediatr. 1990 May;116(5):714-9
pubmed: 2109790
Int J Chron Obstruct Pulmon Dis. 2016 Sep 13;11:2091-2097
pubmed: 27695305
Glob J Health Sci. 2013 Sep 16;5(6):131-41
pubmed: 24171881
J Cyst Fibros. 2009 Jul;8(4):245-52
pubmed: 19481983
Respirology. 2018 Jan;23(1):46-54
pubmed: 28718995
J Psychosom Res. 2011 Feb;70(2):161-7
pubmed: 21262419
Acta Paediatr Scand Suppl. 1989;363:52-6; discussion 56-7
pubmed: 2701925
Int J Chron Obstruct Pulmon Dis. 2020 Jan 29;15:201-212
pubmed: 32099345
J Cyst Fibros. 2017 May;16(3):425-432
pubmed: 27986494
Radiology. 2002 Dec;225(3):663-72
pubmed: 12461244