A novel intronic circular RNA circFGFR1
Male
Humans
Receptor, Fibroblast Growth Factor, Type 1
/ genetics
RNA, Circular
/ genetics
Introns
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Prostatic Neoplasms
/ pathology
Cell Proliferation
/ genetics
MicroRNAs
/ genetics
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
RNA-Binding Protein FUS
/ genetics
FGFR1
FUS
P65
Prostate cancer
Transcription regulation
circRNA
miRNA
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
received:
25
08
2023
accepted:
10
11
2023
medline:
24
11
2023
pubmed:
23
11
2023
entrez:
23
11
2023
Statut:
epublish
Résumé
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due to gene amplification, chromosome rearrangement, point mutation, and epigenetic deregulations, have been reported in various cancers. FGFR1 overexpression has also been reported in prostate cancer (PCa), but the underlining mechanisms are not clear. Here we report a novel circular RNA, circFGFR1
Identifiants
pubmed: 37993879
doi: 10.1186/s12967-023-04718-y
pii: 10.1186/s12967-023-04718-y
pmc: PMC10664560
doi:
Substances chimiques
Receptor, Fibroblast Growth Factor, Type 1
EC 2.7.10.1
RNA, Circular
0
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
MicroRNAs
0
FGFR1 protein, human
EC 2.7.10.1
FUS protein, human
0
RNA-Binding Protein FUS
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
840Subventions
Organisme : National Natural Science Foundation of China
ID : 82273073
Organisme : National Natural Science Foundation of China
ID : 82273047
Organisme : National Natural Science Foundation of China
ID : 81872108
Organisme : National Natural Science Foundation of China
ID : 81872107
Organisme : National Natural Science Foundation of China
ID : 82203315
Organisme : National Natural Science Foundation of China
ID : 82203280
Informations de copyright
© 2023. The Author(s).
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