Skull bone marrow channels as immune gateways to the central nervous system.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
16
11
2022
accepted:
10
10
2023
medline:
4
12
2023
pubmed:
24
11
2023
entrez:
23
11
2023
Statut:
ppublish
Résumé
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called 'skull channels') connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS. We explore the role of this hematopoietic output on CNS health, focusing on the supply of immune cells during health and disease.
Identifiants
pubmed: 37996526
doi: 10.1038/s41593-023-01487-1
pii: 10.1038/s41593-023-01487-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2052-2062Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : NS127808
Informations de copyright
© 2023. Springer Nature America, Inc.
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