Personalized bioceramic grafts for craniomaxillofacial bone regeneration.

Humans Bone Regeneration / physiology Ceramics / chemistry Printing, Three-Dimensional Tissue Scaffolds Biocompatible Materials / chemistry Tissue Engineering / methods Facial Bones / surgery Bone Transplantation / methods Skull / surgery Bone Substitutes

Journal

International journal of oral science
ISSN: 2049-3169
Titre abrégé: Int J Oral Sci
Pays: India
ID NLM: 101504351

Informations de publication

Date de publication:
31 Oct 2024
Historique:
received: 24 04 2024
accepted: 20 09 2024
revised: 16 09 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitantly with the new bone tissue formation, making them ideal as synthetic grafts. This review delves into the key advances of bioceramic grafts/scaffolds obtained by 3D printing for personalized craniomaxillofacial bone reconstruction. In this regard, clinically relevant topics such as ceramic-based biomaterials, graft/scaffold characteristics (macro/micro-features), material extrusion-based 3D printing, and the step-by-step workflow to engineer personalized bioceramic grafts are discussed. Importantly, in vitro models are highlighted in conjunction with a thorough examination of the signaling pathways reported when investigating these bioceramics and their effect on cellular response/behavior. Lastly, we summarize the clinical potential and translation opportunities of personalized bioceramics for craniomaxillofacial bone regeneration.

Identifiants

DOI: 10.1038/s41368-024-00327-7 PMID: 39482290
pubmed: 39482290
doi: 10.1038/s41368-024-00327-7
pii: 10.1038/s41368-024-00327-7
doi:

Substances chimiques

Biocompatible Materials 0
Bone Substitutes 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

62

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR)
ID : R01DE031476

Informations de copyright

© 2024. The Author(s).

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Auteurs

Ana Beatriz G de Carvalho (ABG)

Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Department of Dental Materials and Prosthodontics, São Paulo State University, São José dos Campos, SP, Brazil.

Maedeh Rahimnejad (M)

Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Rodrigo L M S Oliveira (RLMS)

Federal University of São Paulo, Institute of Science and Technology, São José dos Campos, SP, Brazil.

Prabaha Sikder (P)

Department of Mechanical Engineering, Cleveland State University, Cleveland, OH, USA.

Guilherme S F A Saavedra (GSFA)

Department of Dental Materials and Prosthodontics, São Paulo State University, São José dos Campos, SP, Brazil.

Sarit B Bhaduri (SB)

Department of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH, USA.

Debby Gawlitta (D)

Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Regenerative Medicine Center Utrecht, Utrecht, The Netherlands.

Jos Malda (J)

Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Regenerative Medicine Center Utrecht, Utrecht, The Netherlands.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
ORCID: 0000-0002-9241-7676

Darnell Kaigler (D)

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA.

Eliandra S Trichês (ES)

Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Federal University of São Paulo, Institute of Science and Technology, São José dos Campos, SP, Brazil.

Marco C Bottino (MC)

Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA. mbottino@umich.edu.
Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA. mbottino@umich.edu.

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