Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction.

Humans Lipodystrophy, Familial Partial Adipocytes, Brown / metabolism Lamin Type A / metabolism Mineralocorticoid Receptor Antagonists / metabolism Spironolactone / pharmacology Receptors, Mineralocorticoid / metabolism HEK293 Cells Adipose Tissue, Brown / metabolism
adipose tissue lamin A/C mineralocorticoid receptor (MR) prelamin A spironolactone type 2 familial partial lipodystrophy (FPLD2)

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
07 Nov 2023
Historique:
received: 08 09 2023
revised: 29 10 2023
accepted: 02 11 2023
medline: 27 11 2023
pubmed: 24 11 2023
entrez: 24 11 2023
Statut: epublish

Résumé

Type-2 Familial Partial Lipodystrophy (FPLD2), a rare lipodystrophy caused by

Identifiants

DOI: 10.3390/cells12222586 PMID: 37998321 PMC: PMC10670260
pubmed: 37998321
pii: cells12222586
doi: 10.3390/cells12222586
pmc: PMC10670260
pii:
doi:

Substances chimiques

Lamin Type A 0
Mineralocorticoid Receptor Antagonists 0
Spironolactone 27O7W4T232
Receptors, Mineralocorticoid 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian MUR PRIN
ID : Prot. 20223WFJJ3
Organisme : AIPROSAB
ID : grant Prot. 3/2021 "TARGETS" and Prot. 3/2022 "PRE-RECEPTORS
Organisme : IRCCS San Raffaele Institutional fundings
ID : Ricerca corrente to M.C.

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Auteurs

Elisa Schena (E)

Unit of Bologna, CNR-National Research Council of Italy, Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", 40136 Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
ORCID: 0000-0001-5960-4157

Elisabetta Mattioli (E)

Unit of Bologna, CNR-National Research Council of Italy, Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", 40136 Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

Chiara Peres (C)

Unit of Bologna, CNR-National Research Council of Italy, Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", 40136 Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
ORCID: 0000-0003-0740-2013

Laura Zanotti (L)

Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.

Paolo Morselli (P)

Plastic Surgery Unit, Department of Specialised, Experimental and Diagnostic Medicine, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, 40126 Bologna, Italy.

Patricia Iozzo (P)

CNR-National Research Council of Italy, Institute of Clinical Physiology, 56124 Pisa, Italy.
ORCID: 0000-0001-6443-7074

Maria Angela Guzzardi (MA)

CNR-National Research Council of Italy, Institute of Clinical Physiology, 56124 Pisa, Italy.

Chiara Bernardini (C)

Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy.
ORCID: 0000-0003-3384-0244

Monica Forni (M)

Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
ORCID: 0000-0003-1310-6202

Salvatore Nesci (S)

Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy.
ORCID: 0000-0001-8569-7158

Massimiliano Caprio (M)

Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele, 00163 Rome, Italy.
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy.
ORCID: 0000-0003-0722-7163

Carolina Cecchetti (C)

Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.

Uberto Pagotto (U)

Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
ORCID: 0000-0003-4182-3110

Elena Gabusi (E)

SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

Luca Cattini (L)

SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

Gina Lisignoli (G)

SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
ORCID: 0000-0003-2837-9967

William Blalock (W)

Unit of Bologna, CNR-National Research Council of Italy, Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", 40136 Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
ORCID: 0000-0002-8045-4840

Alessandra Gambineri (A)

Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.

Giovanna Lattanzi (G)

Unit of Bologna, CNR-National Research Council of Italy, Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", 40136 Bologna, Italy.
IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
ORCID: 0000-0002-7103-8722

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Dermatoses métaboliques › Lipodystrophie › Lipodystrophie partielle familiale › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Adipocytes bruns › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines associées à la matrice nucléaire › Lamines › Lamine A › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Diurétiques › Diurétiques d'épargne potassique › Antagonistes des récepteurs des minéralocorticoïdes › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Spironolactone › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs des minéralocorticoïdes › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Mineralocorticoid Receptor Antagonism Prevents...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Mineralocorticoid Receptor Antagonism Prevents...