Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease.
Crohn’s disease
JAK inhibitor
colon cancer
inflammation
inflammatory bowel disease
kinase
ulcerative colitis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
06 Nov 2023
06 Nov 2023
Historique:
received:
29
06
2023
revised:
27
10
2023
accepted:
29
10
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Colorectal cancer is a known complication of chronic inflammation of the colon ("colitis-associated colon cancer"). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk of colon cancer compared to the general population. Kinase signaling pathways play critical roles in both the inflammation and regulating cellular processes such as proliferation and survival that contribute to cancer development. Here we review the interplay of kinase signaling pathways (mitogen-activated protein kinases, cyclin-dependent kinases, autophagy-activated kinases, JAK-STAT, and other kinases) and their effects on colitis-associated colon cancer. We also discuss the role of JAK-STAT signaling in the pathogenesis of IBD and the therapeutic landscape of JAK inhibitors for the treatment of IBD.
Identifiants
pubmed: 38002302
pii: biom13111620
doi: 10.3390/biom13111620
pmc: PMC10669043
pii:
doi:
Substances chimiques
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : L30 DK126220
Pays : United States
Organisme : NIDDK NIH HHS
ID : 2L30 DK126220
Pays : United States
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