C8ORF88: A Novel eIF4E-Binding Protein.
C8ORF88
cap-dependent translation
eIF4E
gene expression
mRNA
protein synthesis
translation initiation
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
14 Nov 2023
14 Nov 2023
Historique:
received:
04
08
2023
revised:
03
11
2023
accepted:
09
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Translation initiation in eukaryotes is regulated at several steps, one of which involves the availability of the cap binding protein to participate in cap-dependent protein synthesis. Binding of eIF4E to translational repressors (eIF4E-binding proteins [4E-BPs]) suppresses translation and is used by cells to link extra- and intracellular cues to protein synthetic rates. The best studied of these interactions involves repression of translation by 4E-BP1 upon inhibition of the PI3K/mTOR signaling pathway. Herein, we characterize a novel 4E-BP, C8ORF88, whose expression is predominantly restricted to early spermatids. C8ORF88:eIF4E interaction is dependent on the canonical eIF4E binding motif (4E-BM) present in other 4E-BPs. Whereas 4E-BP1:eIF4E interaction is dependent on the phosphorylation of 4E-BP1, these sites are not conserved in C8ORF88 indicating a different mode of regulation.
Identifiants
pubmed: 38003019
pii: genes14112076
doi: 10.3390/genes14112076
pmc: PMC10670996
pii:
doi:
Substances chimiques
Carrier Proteins
0
Eukaryotic Initiation Factor-4E
0
Phosphoproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : FDN-148366
Pays : Canada
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