Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.

Reactive Oxygen Species / metabolism Antioxidants / metabolism Inflammasomes / metabolism Oxidative Stress Peroxiredoxin VI / genetics Epithelial Cells / metabolism NLR Family, Pyrin Domain-Containing 3 Protein / genetics
Caspase-1 GSDMD IL-1β NF-ĸB Nlrp3 Peroxiredoxin 6 oxidative stress

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Nov 2023
Historique:
received: 15 10 2023
revised: 06 11 2023
accepted: 08 11 2023
medline: 27 11 2023
pubmed: 25 11 2023
entrez: 25 11 2023
Statut: epublish

Résumé

The continuum of antioxidant response dysregulation in aging/oxidative stress-driven Nlrp3 inflammasome activation-mediated inflammatory response is associated with age-related diseases. Peroxiredoxin (Prdx) 6 is a key antioxidant that provides cytoprotection by regulating redox homeostasis. Herein, using lens epithelial cells (LECs) derived from the targeted inactivation of Prdx6 gene and aging lenses, we present molecular evidence that

Identifiants

DOI: 10.3390/ijms242216276 PMID: 38003466 PMC: PMC10671722
pubmed: 38003466
pii: ijms242216276
doi: 10.3390/ijms242216276
pmc: PMC10671722
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
Antioxidants 0
Inflammasomes 0
Peroxiredoxin VI EC 1.11.1.15
NLR Family, Pyrin Domain-Containing 3 Protein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NEI NIH HHS
ID : R01 EY024589
Pays : United States
Organisme : NEI NIH HHS
ID : EY024598
Pays : United States

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Auteurs

Bhavana Chhunchha (B)

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
ORCID: 0000-0001-9613-8765

Rakesh Kumar (R)

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Eri Kubo (E)

Department of Ophthalmology, Kanazawa Medical University, Kahoku 9200293, Ishikawa, Japan.
ORCID: 0000-0001-6789-9311

Priyanka Thakur (P)

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Dhirendra P Singh (DP)

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Peroxirédoxines › Peroxiredoxin VI › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Cellules › Cellules épithéliales › Prdx6 Regulates Nlrp3 Inflammasome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Prdx6 Regulates Nlrp3 Inflammasome...