Frequency Evaluation of the
HFE
IL-6
inflammation
iron metabolism
rheumatoid arthritis
systemic lupus erythematosus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Nov 2023
14 Nov 2023
Historique:
received:
19
10
2023
revised:
10
11
2023
accepted:
11
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Autoimmune diseases are generally characterized by a multifactorial etiology and are often associated with a genetic predisposition. Both iron metabolism and the inflammatory cytokine system have been shown to play a pivotal role in the dysregulation of the immune response in many different autoimmune conditions, rheumatologic diseases included. The purpose of this work was to analyze the frequency of mutations altering the expression of IL-6 or influencing iron metabolism in patients affected by autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). In this study, 144 patients were enrolled: 77 and 67 patients were affected by RA and SLE, respectively. In these cohorts, the frequency of the
Identifiants
pubmed: 38003490
pii: ijms242216300
doi: 10.3390/ijms242216300
pmc: PMC10671518
pii:
doi:
Substances chimiques
Interleukin-6
0
Iron
E1UOL152H7
HFE protein, human
0
Hemochromatosis Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Brescia
ID : Ex60% Biasiotto
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