Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.
Alzheimer’s disease
Behavioral and psychological symptoms of dementia
Frontotemporal dementia
Mixed dementia
Parkinson’s disease
Vascular dementia
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
08
09
2023
accepted:
07
11
2023
medline:
18
3
2024
pubmed:
28
11
2023
entrez:
28
11
2023
Statut:
ppublish
Résumé
The aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings obtained from studies in patients with apathy in different forms of dementia, including Alzheimer's disease (AD), vascular (VaD) and mixed dementia, frontotemporal dementia (FTD), and Parkinson's disease dementia (PDD). Randomized controlled trials, non-randomized controlled trials, controlled before-after studies, and interrupted time series from four databases (WebOfScience, Scopus, Pubmed, and PsycINFO) addressing apathy in adults or older people aged over 65 years of age affected by dementia were included. The prevalence of apathy was 26-82% for AD, 28.6-91.7 for VaD, 29-97.5% in PDD, and 54.8-88.0 in FTD. The assessment of apathy was not consistent in the reviewed studies. Methylphenidate was the most successful pharmacological treatment for apathy. Neurobiological studies highlighted the relationship between both structural and functional brain areas and the presence or severity of apathy. Apathy is a very common disorder in all types of dementia, although it is often underdiagnosed and undertreated. Further studies are needed to investigate its diagnosis and management. A consensus on the different evaluation scales should be achieved.
Identifiants
pubmed: 38015288
doi: 10.1007/s10072-023-07197-7
pii: 10.1007/s10072-023-07197-7
pmc: PMC10942903
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1343-1376Informations de copyright
© 2023. The Author(s).
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