T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19.

Humans COVID-19 CD8-Positive T-Lymphocytes SARS-CoV-2 Vaccination Antibodies, Viral

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
29 Nov 2023
Historique:
medline: 1 12 2023
pubmed: 29 11 2023
entrez: 29 11 2023
Statut: ppublish

Résumé

Individuals with primary and pharmacologic B cell deficiencies have high rates of severe disease and mortality from coronavirus disease 2019 (COVID-19), but the immune responses and clinical outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination have yet to be fully defined. Here, we evaluate the cellular immune responses after both SARS-CoV-2 infection and vaccination in patients receiving the anti-CD20 therapy rituximab (RTX) and those with low B cell counts due to common variable immune deficiency (CVID) disease. Assessment of effector and memory CD4

Identifiants

DOI: 10.1126/scitranslmed.adh4529 PMID: 38019932
pubmed: 38019932
doi: 10.1126/scitranslmed.adh4529
doi:

Substances chimiques

Antibodies, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadh4529

Auteurs

Reza Zonozi (R)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0002-7389-4549

Lucy C Walters (LC)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
ORCID: 0000-0002-8406-2828

Aaron Shulkin (A)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0002-3751-6604

Vivek Naranbhai (V)

Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa.
Monash University, Melbourne, VIC 3022, Australia.
ORCID: 0000-0003-4281-8882

Pravarut Nithagon (P)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0009-0007-4960-5042

Gabriel Sauvage (G)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0001-9485-491X

Clarety Kaeske (C)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.

Katherine Cosgrove (K)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0009-0009-4238-2581

Anusha Nathan (A)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Program in Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA 02115, USA.

Rhoda Tano-Menka (R)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.

Alton C Gayton (AC)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0002-2411-0621

Matthew A Getz (MA)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0002-4172-2187

Fernando Senjobe (F)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0003-4322-6571

Daniel Worrall (D)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
ORCID: 0000-0002-7760-9848

A John Iafrate (AJ)

Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0002-7888-4067

Caroline Fromson (C)

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Sydney B Montesi (SB)

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Deepak A Rao (DA)

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-9672-7746

Jeffrey A Sparks (JA)

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-5556-4618

Zachary S Wallace (ZS)

Division of Rheumatology, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0003-4708-7038

Jocelyn R Farmer (JR)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Division of Allergy and Inflammation, Beth Israel Lahey Health, Boston, MA 02215, USA.
ORCID: 0000-0003-4901-9848

Bruce D Walker (BD)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa.
Broad Institute, Cambridge, MA 02142, USA.
Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Institute for Medical Engineering and Science and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-6122-9245

Richelle C Charles (RC)

Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0002-8881-1849

Karen Laliberte (K)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0009-0003-0223-2796

John L Niles (JL)

Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0009-0003-4072-6535

Gaurav D Gaiha (GD)

Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
ORCID: 0000-0001-6875-4472

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T cell responses to SARS-CoV-2 infection and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › T cell responses to SARS-CoV-2 infection and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › T cell responses to SARS-CoV-2 infection and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › T cell responses to SARS-CoV-2 infection and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › T cell responses to SARS-CoV-2 infection and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › T cell responses to SARS-CoV-2 infection and...