Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial.
cardiometabolic health
fasting plasma cortisol
insulin resistance
lifestyle intervention
mediterranean diet
weight loss
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
06
2023
accepted:
23
10
2023
medline:
4
12
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
epublish
Résumé
Fasting morning cortisol (FMC) stress hormone levels, are suggested to reflect increased cardiometabolic risk. Acute response to weight loss diet could elevate FMC. Richer Polyphenols and lower carbohydrates diets could favor FMC levels. We aimed to explore the effect of long-term high polyphenol Mediterranean diet (green-MED) on FMC and its relation to metabolic health. We randomized 294 participants into one of three dietary interventions for 18-months: healthy dietary guidelines (HDG), Mediterranean (MED) diet, and Green-MED diet. Both MED diets were similarly hypocaloric and lower in carbohydrates and included walnuts (28 g/day). The high-polyphenols/low-meat Green-MED group further included green tea (3-4 cups/day) and a Wolffia-globosa Mankai plant 1-cup green shakeFMC was obtained between 07:00-07:30AM at baseline, six, and eighteen-months. Participants (age=51.1years, 88% men) had a mean BMI of 31.3kg/m Long-term adherence to MED diets, and mainly green-MED/high polyphenols diet, may lower FMC, stress hormone, levels,. Lifestyle-induced FMC decrease may have potential benefits related to cardiometabolic health, irrespective of weight loss. ClinicalTrials.gov, identifier NCT03020186.
Sections du résumé
Background
UNASSIGNED
Fasting morning cortisol (FMC) stress hormone levels, are suggested to reflect increased cardiometabolic risk. Acute response to weight loss diet could elevate FMC. Richer Polyphenols and lower carbohydrates diets could favor FMC levels. We aimed to explore the effect of long-term high polyphenol Mediterranean diet (green-MED) on FMC and its relation to metabolic health.
Methods
UNASSIGNED
We randomized 294 participants into one of three dietary interventions for 18-months: healthy dietary guidelines (HDG), Mediterranean (MED) diet, and Green-MED diet. Both MED diets were similarly hypocaloric and lower in carbohydrates and included walnuts (28 g/day). The high-polyphenols/low-meat Green-MED group further included green tea (3-4 cups/day) and a Wolffia-globosa Mankai plant 1-cup green shakeFMC was obtained between 07:00-07:30AM at baseline, six, and eighteen-months.
Results
UNASSIGNED
Participants (age=51.1years, 88% men) had a mean BMI of 31.3kg/m
Conclusion
UNASSIGNED
Long-term adherence to MED diets, and mainly green-MED/high polyphenols diet, may lower FMC, stress hormone, levels,. Lifestyle-induced FMC decrease may have potential benefits related to cardiometabolic health, irrespective of weight loss.
Clinical trial registration
UNASSIGNED
ClinicalTrials.gov, identifier NCT03020186.
Identifiants
pubmed: 38034010
doi: 10.3389/fendo.2023.1243910
pmc: PMC10682947
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
C-Reactive Protein
9007-41-4
Glycated Hemoglobin
0
Testosterone
3XMK78S47O
Thyrotropin
9002-71-5
Banques de données
ClinicalTrials.gov
['NCT03020186']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1243910Informations de copyright
Copyright © 2023 Alufer, Tsaban, Rinott, Kaplan, Meir, Zelicha, Ceglarek, Isermann, Blüher, Stumvoll, Stampfer and Shai.
Déclaration de conflit d'intérêts
IS advises the nutritional committee of Hinoman, Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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