Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion.

Humans Receptors, Chimeric Antigen / genetics Peptides / chemistry Epitopes Antigens, Neoplasm

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
12 2023
Historique:
medline: 4 12 2023
pubmed: 1 12 2023
entrez: 1 12 2023
Statut: ppublish

Résumé

Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy for targeted cancer therapy. We have previously developed a PC-CAR targeting a neuroblastoma-associated PHOX2B peptide, leading to robust tumor cell lysis restricted by two common HLA allotypes. Here, we determine the 2.1-angstrom crystal structure of the PC-CAR-PHOX2B-HLA-A*24:02-β

Identifiants

DOI: 10.1126/sciimmunol.adj5792 PMID: 38039376
pubmed: 38039376
doi: 10.1126/sciimmunol.adj5792
doi:

Substances chimiques

Receptors, Chimeric Antigen 0
Peptides 0
Epitopes 0
Antigens, Neoplasm 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj5792

Commentaires et corrections

Type : UpdateOf

Auteurs

Yi Sun (Y)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-7821-4346

Tyler J Florio (TJ)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Sagar Gupta (S)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-2151-9018

Michael C Young (MC)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-8420-2149

Quinlen F Marshall (QF)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0002-4736-9716

Samuel E Garfinkle (SE)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-7729-9299

Georgia F Papadaki (GF)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0003-0630-2248

Hau V Truong (HV)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-0059-2793

Emily Mycek (E)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0009-0000-1919-3648

Peiyao Li (P)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0001-9119-2498

Alvin Farrel (A)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-1087-9840

Nicole L Church (NL)

Myrio Tx, Melbourne, Victoria, Australia.

Shereen Jabar (S)

Myrio Tx, Melbourne, Victoria, Australia.

Matthew D Beasley (MD)

Myrio Tx, Melbourne, Victoria, Australia.
ORCID: 0000-0002-6046-8516

Ben R Kiefel (BR)

Myrio Tx, Melbourne, Victoria, Australia.

Mark Yarmarkovich (M)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-4638-2019

Leena Mallik (L)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-5979-7494

John M Maris (JM)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-8088-7929

Nikolaos G Sgourakis (NG)

Center for Computational and Genomic Medicine and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0003-3655-3902

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural principles of peptide-centric...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › Structural principles of peptide-centric...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Structural principles of peptide-centric...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Structural principles of peptide-centric...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Structural principles of peptide-centric...