Evolution of Biocatalysis at Novartis over the last 40 Years.

Biocatalysis
Biocatalysis Bioinformatics Enzyme evolution Late-stage functionalization Metabolite synthesis

Journal

Chimia
ISSN: 0009-4293
Titre abrégé: Chimia (Aarau)
Pays: Switzerland
ID NLM: 0373152

Informations de publication

Date de publication:
28 Jun 2023
Historique:
received: 10 03 2023
accepted: 16 05 2023
medline: 5 12 2023
pubmed: 4 12 2023
entrez: 4 12 2023
Statut: epublish

Résumé

The fortieth anniversary of biocatalysis started at Ciba-Geigy and later at Novartis is a great time to pause and reflect on development of science and technology in this field. Enzyme-based synthesis became a highly valued enabling tool for pharmaceutical research and development over the last decades. In this perspective we aim to discuss how the scientific approaches and trends evolved over the time and present future challenges and opportunities.

Identifiants

DOI: 10.2533/chimia.2023.376 PMID: 38047776
pubmed: 38047776
doi: 10.2533/chimia.2023.376
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

376-383

Informations de copyright

Copyright 2023 Elina Siirola, Fabian Eggimann, Charles Moore, Kirsten Schroer, Alexandra Vargas, Theo Peschke, Thierry Schlama, Radka Snajdrova. License: This work is licensed under a Creative Commons Attribution 4.0 International License.

Auteurs

Elina Siirola (E)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. elina.siirola@novartis.com.

Fabian Eggimann (F)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. fabian_kurt.eggimann@novartis.com.

Charles Moore (C)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. charles-1.moore@novartis.com.

Kirsten Schroer (K)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. kirsten.schroer@novartis.com.

Alexandra Vargas (A)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. alexandra.vargas@novartis.com.

Theo Peschke (T)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. theo.peschke@novartis.com.

Thierry Schlama (T)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. thierry.schlama@novartis.com.

Radka Snajdrova (R)

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, CH-4108. radka.snajdrova@novartis.com.

Articles similaires

Perspectives of aminoacylases in biocatalytic synthesis of N-acyl-amino acids surfactants.

Gerrit Haeger, Jessika Wirges, Johannes Bongaerts et al.
1.00
Surface-Active Agents Amino Acids Biocatalysis Amidohydrolases Substrate Specificity

Machine learning-assisted amidase-catalytic enantioselectivity prediction and rational design of variants for improving enantioselectivity.

Zi-Lin Li, Shuxin Pei, Ziying Chen et al.
1.00
Machine Learning Biocatalysis Stereoisomerism Amidohydrolases Protein Engineering

Comprehensive Insights into Microbial Lipases: Unveiling Structural Dynamics, Catalytic Mechanism, and Versatile Applications.

Haroon Shah, Chengnan Zhang, Sohail Khan et al.
1.00
Lipase Bacteria Fungi Biocatalysis Substrate Specificity

Enhanced Immobilization of Enzymes on Plasma Micro-Nanotextured Surfaces and Microfluidics: Application to HRP.

Stefania Vorvi, Katerina Tsougeni, Angeliki Tserepi et al.
1.00
Enzymes, Immobilized Horseradish Peroxidase Polymethyl Methacrylate Surface Properties Microfluidics

Classifications MeSH

questionsmedicales.fr › Métabolisme › Biocatalyse › Evolution of Biocatalysis at Novartis over the...