Enantioselective Switch and Potential Applications in Biocatalysis.

Biocatalysis Stereoisomerism Transaminases
Biocatalysis Enantiopreference Enzymes Transaminase

Journal

Chimia
ISSN: 0009-4293
Titre abrégé: Chimia (Aarau)
Pays: Switzerland
ID NLM: 0373152

Informations de publication

Date de publication:
28 Jun 2023
Historique:
received: 14 03 2023
accepted: 12 05 2023
medline: 5 12 2023
pubmed: 4 12 2023
entrez: 4 12 2023
Statut: epublish

Résumé

Enantioselectivity has always been a key feature of enzymatic synthesis. In some cases, when enzymes are not strictly enantioselective, by tuning the reaction conditions it is possible to induce an enantioselective switch. A transaminase from Halomonas elongata (ω-HeWT), while generally S-selective, could be shifted towards generating the R-enantiomer at higher concentrations of amino acceptor or ionic strength, for example. Other enzymes are reported to have a similar behavior, and here we discuss some of them and their potential applications.

Identifiants

DOI: 10.2533/chimia.2023.390 PMID: 38047778
pubmed: 38047778
doi: 10.2533/chimia.2023.390
doi:

Substances chimiques

Transaminases EC 2.6.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

390-394

Subventions

Organisme : Swiss National Science Foundation
ID : 200021_192274
Pays : Switzerland

Informations de copyright

Copyright 2023 Lucia Robustini, Francesca Paradisi. License: This work is licensed under a Creative Commons Attribution 4.0 International License.

Auteurs

Lucia Robustini (L)

Dept. Chemistry, Biochemistry and Pharmaceutical Sciences. University of Bern, Freiestrasse 3, CH-3012 Bern. lucia.robustini@unibe.ch.

Francesca Paradisi (F)

Dept. Chemistry, Biochemistry and Pharmaceutical Sciences. University of Bern, Freiestrasse 3, CH-3012 Bern. francesca.paradisi@unibe.ch.
ORCID: 0000-0003-1704-0642

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Biocatalyse › Enantioselective Switch and Potential...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Enantioselective Switch and Potential...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Enantioselective Switch and Potential...