A Population Model of Time-Dependent Changes in Serum Creatinine in (Near)term Neonates with Hypoxic-Ischemic Encephalopathy During and After Therapeutic Hypothermia.
acute kidney injury
hypoxic-ischemic encephalopathy
neonates
population model
serum creatinine
therapeutic hypothermia
time-dependent covariate
Journal
The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209
Informations de publication
Date de publication:
05 12 2023
05 12 2023
Historique:
received:
21
04
2023
accepted:
16
08
2023
medline:
7
12
2023
pubmed:
5
12
2023
entrez:
5
12
2023
Statut:
epublish
Résumé
The objective was to apply a population model to describe the time course and variability of serum creatinine (sCr) in (near)term neonates with moderate to severe encephalopathy during and after therapeutic hypothermia (TH). The data consisted of sCr observations up to 10 days of postnatal age in neonates who underwent TH during the first 3 days after birth. Available covariates were birth weight (BWT), gestational age (GA), survival, and acute kidney injury (AKI). A previously published population model of sCr kinetics in neonates served as the base model. This model predicted not only sCr but also the glomerular filtration rate normalized by its value at birth (GFR/GFR
Identifiants
pubmed: 38051395
doi: 10.1208/s12248-023-00851-0
pii: 10.1208/s12248-023-00851-0
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4Subventions
Organisme : NICHD NIH HHS
ID : P30 HD106451
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
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