An inorganic mineral-based protocell with prebiotic radiation fitness.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 Dec 2023
05 Dec 2023
Historique:
received:
03
07
2023
accepted:
06
11
2023
medline:
7
12
2023
pubmed:
6
12
2023
entrez:
5
12
2023
Statut:
epublish
Résumé
Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of life. However, little is known about protocell's survival and fitness under prebiotic radiations. Here we present a radioresistant protocell model based on assembly of two types of coacervate droplets, which are formed through interactions of inorganic polyphosphate (polyP) with divalent metal cation and cationic tripeptide, respectively. Among the coacervate droplets, only the polyP-Mn droplet is radiotolerant and provides strong protection for recruited proteins. The radiosensitive polyP-tripeptide droplet sequestered with both proteins and DNA could be encapsulated inside the polyP-Mn droplet, and form into a compartmentalized protocell. The protocell protects the inner nucleoid-like condensate through efficient reactive oxygen species' scavenging capacity of intracellular nonenzymic antioxidants including Mn-phosphate and Mn-peptide. Our results demonstrate a radioresistant protocell model with redox reaction system in response to ionizing radiation, which might enable the protocell fitness to prebiotic radiation on the primitive Earth preceding the emergence of enzyme-based fitness. This protocell might also provide applications in synthetic biology as bioreactor or drug delivery system.
Identifiants
pubmed: 38052788
doi: 10.1038/s41467-023-43272-5
pii: 10.1038/s41467-023-43272-5
pmc: PMC10698201
doi:
Substances chimiques
Peptides
0
Proteins
0
Minerals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7699Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32170028
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32200020
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : U1967217
Informations de copyright
© 2023. The Author(s).
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