Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.

Male Humans Female Hyperuricemia / complications Osteoarthritis / epidemiology Hand Joints / diagnostic imaging Hand Prospective Studies
arthritis epidemiology osteoarthritis

Journal

RMD open
ISSN: 2056-5933
Titre abrégé: RMD Open
Pays: England
ID NLM: 101662038

Informations de publication

Date de publication:
01 12 2023
Historique:
received: 04 09 2023
accepted: 13 11 2023
medline: 7 12 2023
pubmed: 6 12 2023
entrez: 6 12 2023
Statut: epublish

Résumé

The pathogenesis of hand osteoarthritis (OA) remains unknown. Hyperuricaemia, which is related to inflammation, may play a role in hand OA, but evidence is lacking. In a large population-based study, we examined the association between hyperuricaemia and hand OA. Participants were from the Xiangya OA Study, a community-based observational study. Hyperuricaemia was defined as serum urate >416 µmol/L in men and >357 µmol/L in women. Radiographic hand OA (RHOA) was defined as presence of the modified Kellgren-Lawrence grade ≥2 in any hand joint. Symptomatic hand OA (SHOA) was defined as presence of both self-reported symptoms and RHOA in the same hand. The associations of hyperuricaemia with RHOA or SHOA were examined using generalised estimating equations. Among 3628 participants, the prevalence of RHOA was higher in participants with hyperuricaemia than those with normouricaemia (26.9% vs 20.9%), with an adjusted OR (aOR) of 1.34 (95% CI 1.11 to 1.61). The associations were consistent in men (aOR 1.33, 95% CI 1.01 to 1.74) and women (aOR 1.35, 95% CI 1.05 to 1.74). Hyperuricaemia was mainly associated with bilateral RHOA (aOR 1.54, 95% CI 1.18 to 2.01) but not unilateral RHOA (aOR 1.13, 95% CI 0.89 to 1.45). Prevalence of SHOA was higher, although statistically insignificant, in participants with hyperuricaemia (aOR 1.39, 95% CI 0.94 to 2.07). In this population-based study, hyperuricaemia was associated with a higher prevalence of hand OA. Future prospective studies are required to investigate the temporal relationship. NCT04033757.

Identifiants

DOI: 10.1136/rmdopen-2023-003683 PMID: 38053456 PMC: PMC10693871
pubmed: 38053456
pii: rmdopen-2023-003683
doi: 10.1136/rmdopen-2023-003683
pmc: PMC10693871
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT04033757']

Types de publication

Observational Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Références

Arthritis Res Ther. 2021 Jun 2;23(1):156
pubmed: 34078472
Osteoarthritis Cartilage. 2020 Jan;28(1):7-9
pubmed: 31408694
Eur Rev Med Pharmacol Sci. 2022 Sep;26(18):6600-6607
pubmed: 36196710
Nat Rev Rheumatol. 2018 Nov;14(11):641-656
pubmed: 30305701
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
Lancet. 2019 Aug 24;394(10199):639-651
pubmed: 31327564
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2088-93
pubmed: 21245324
Osteoarthritis Cartilage. 2022 Feb;30(2):184-195
pubmed: 34534661
Arthritis Rheumatol. 2022 Apr;74(4):682-691
pubmed: 34725964
J Rheumatol. 1996 Jul;23(7):1130-4
pubmed: 8823682
Zhonghua Nei Ke Za Zhi. 2020 Jul 1;59(7):519-527
pubmed: 32594685
Ann Rheum Dis. 2005 May;64(5):682-7
pubmed: 15374852
ISRN Rheumatol. 2014 Feb 16;2014:852954
pubmed: 24693449
Lancet. 2021 May 15;397(10287):1843-1855
pubmed: 33798500
Nutrients. 2023 Sep 30;15(19):
pubmed: 37836522
Nature. 2006 Mar 9;440(7081):237-41
pubmed: 16407889
Joint Bone Spine. 2019 Oct;86(5):576-582
pubmed: 30471419
Lancet. 2019 Apr 27;393(10182):1745-1759
pubmed: 31034380
Clin Orthop Relat Res. 2015 Oct;473(10):3307-14
pubmed: 26162413
Nat Rev Rheumatol. 2020 Feb;16(2):75-86
pubmed: 31822862
N Engl J Med. 2008 Oct 23;359(17):1811-21
pubmed: 18946066
Stat Med. 2014 May 10;33(10):1685-99
pubmed: 24323618
Ann Rheum Dis. 2011 Sep;70(9):1581-6
pubmed: 21622766
Clin Rev Allergy Immunol. 2023 Apr;64(2):222-238
pubmed: 35716253
Ann Intern Med. 2018 Aug 7;169(3):156-164
pubmed: 29913486
Rheumatol Int. 2016 Apr;36(4):567-73
pubmed: 26743214
Osteoarthritis Cartilage. 2019 Sep;27(9):1301-1308
pubmed: 31158484
Cell Biol Int. 2002;26(3):297-300
pubmed: 11991658
Ann Rheum Dis. 2015 Sep;74(9):1720-4
pubmed: 24782463
Osteoarthritis Cartilage. 2022 Jan;30(1):10-16
pubmed: 34023527
Nat Rev Rheumatol. 2022 Mar;18(3):171-183
pubmed: 35105980
RMD Open. 2020 Jun;6(2):
pubmed: 32584781
Arthritis Rheumatol. 2021 Sep;73(9):1656-1662
pubmed: 33760399
Homo. 2011 Aug;62(4):280-7
pubmed: 21565342
Rejuvenation Res. 2017 Feb;20(1):42-49
pubmed: 27241310
Osteoarthritis Cartilage. 2020 Apr;28(4):446-452
pubmed: 32084589
Am J Epidemiol. 2002 Dec 1;156(11):1021-7
pubmed: 12446258
Nat Rev Rheumatol. 2011 Jan;7(1):33-42
pubmed: 21119608
Eur Heart J. 2006 May;27(10):1174-81
pubmed: 16611671
Nat Rev Dis Primers. 2016 Oct 13;2:16072
pubmed: 27734845
J Orthop Sci. 2008 Nov;13(6):487-91
pubmed: 19089534
Rheumatology (Oxford). 2013 Jun;52(6):1018-21
pubmed: 23204548
Arthritis Res Ther. 2017 Oct 24;19(1):236
pubmed: 29065924

Auteurs

Yanqiu Zhu (Y)

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.

Jiatian Li (J)

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.

Yuqing Zhang (Y)

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
ORCID: 0000-0001-7638-0888

Weiya Zhang (W)

Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.
Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham, UK.

Michael Doherty (M)

Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.
Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research, University of Nottingham, Nottingham, UK.

Zidan Yang (Z)

Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.

Yang Cui (Y)

Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha, China.

Chao Zeng (C)

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Guanghua Lei (G)

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
ORCID: 0000-0003-2987-138X

Tuo Yang (T)

Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK weij1988@csu.edu.cn yangtuo@csu.edu.cn.
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.
Health Management Center, Xiangya Hospital, Central South University, Changsha, China.

Jie Wei (J)

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China weij1988@csu.edu.cn yangtuo@csu.edu.cn.
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.
ORCID: 0000-0003-3510-8241

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association between hyperuricaemia and hand...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hyperuricémie › Association between hyperuricaemia and hand...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Association between hyperuricaemia and hand...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulations de la main › Association between hyperuricaemia and hand...
questionsmedicales.fr › Régions du corps › Membres › Membre supérieur › Main › Association between hyperuricaemia and hand...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Association between hyperuricaemia and hand...