Metabolic alterations unravel the maternofetal immune responses with disease severity in pregnant women infected with SARS-CoV-2.
B cells
COVID-19
NAD+
T cells
cytokines
metabolomics
monocytes
placenta
pregnancy
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
27
10
2023
received:
10
05
2023
accepted:
13
11
2023
medline:
7
12
2023
pubmed:
6
12
2023
entrez:
6
12
2023
Statut:
ppublish
Résumé
Pregnancy being an immune compromised state, coronavirus disease of 2019 (COVID-19) disease poses high risk of premature delivery and threat to fetus. Plasma metabolome regulates immune cellular responses, therefore we aimed to analyze the change in plasma secretome, metabolome, and immune cells with disease severity in COVID-19 positive pregnant females and their cord blood. COVID-19 reverse transcriptase-polymerase chain reaction positive pregnant females (n = 112) with asymptomatic (Asy) (n = 82), mild (n = 21), or moderate (n = 9) disease, healthy pregnant (n = 18), COVID-19 positive nonpregnant females (n = 7) were included. Eighty-two cord blood from COVID-19 positive and seven healthy cord blood were also analyzed. Mother's peripheral blood and cord blood were analyzed for untargeted metabolome profiling and cytokines by using high-resolution mass spectrometry and cytokine bead array. Immune scan was performed only in mothers' blood by flow cytometry. In Asy severe acute respiratory syndrome coronavirus 2 infection, the amino acid metabolic pathways such as glycine, serine, l-lactate, and threonine metabolism were upregulated with downregulation of riboflavin and tyrosine metabolism. However, with mild-to-moderate disease, the pyruvate and nicotinamide adenine dinucleotide (NAD
Substances chimiques
Interleukin-9
0
NAD
0U46U6E8UK
Cytokines
0
Interleukin-6
0
Interferon-alpha
0
Pyruvates
0
Glycine
TE7660XO1C
Lactates
0
Riboflavin
TLM2976OFR
Serine
452VLY9402
Threonine
2ZD004190S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29257Subventions
Organisme : Indian Council of Medical Research
Informations de copyright
© 2023 Wiley Periodicals LLC.
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