Promising Outcomes of Modified ALPPS for Staged Hepatectomy in Cholangiocarcinoma.

ALPPS cholangiocarcinoma future liver remnant volume posthepatectomy liver failure

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 27 10 2023
revised: 13 11 2023
accepted: 22 11 2023
medline: 9 12 2023
pubmed: 9 12 2023
entrez: 9 12 2023
Statut: epublish

Résumé

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage procedure that can potentially cure patients with large cholangiocarcinoma. The current study evaluates the impact of modifications on the outcomes of ALPPS in patients with cholangiocarcinoma. In this single-center study, a series of 30 consecutive patients with cholangiocarcinoma (22 extrahepatic and 8 intrahepatic) who underwent ALPPS between 2011 and 2021 was evaluated. The ALPPS procedure in our center was modified in 2016 by minimizing the first stage of the surgical procedure through biliary externalization after the first stage, antibiotic administration during the interstage phase, and performing biliary reconstructions during the second stage. The rate of postoperative major morbidity and 90-day mortality, as well as the one- and three-year disease-free and overall survival rates were calculated and compared between patients operated before and after 2016. The ALPPS risk score before the second stage of the procedure was lower in patients who were operated on after 2016 (before 2016: median 6.4; after 2016: median 4.4;

Identifiants

pubmed: 38067316
pii: cancers15235613
doi: 10.3390/cancers15235613
pmc: PMC10705795
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Arianeb Mehrabi (A)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Mohammad Golriz (M)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Ali Ramouz (A)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Elias Khajeh (E)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Ahmed Hammad (A)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Thilo Hackert (T)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Beat Müller-Stich (B)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Oliver Strobel (O)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Sadeq Ali-Hasan-Al-Saegh (S)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Omid Ghamarnejad (O)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Mohammed Al-Saeedi (M)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Christoph Springfeld (C)

Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.
Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Christian Rupp (C)

Department of Internal Medicine, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Philipp Mayer (P)

Department of Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Markus Mieth (M)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Benjamin Goeppert (B)

Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.
Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Katrin Hoffmann (K)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Liver Cancer Center Heidelberg (LCCH), Heidelberg University Hospital, 69120 Heidelberg, Germany.

Markus W Büchler (MW)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Classifications MeSH