Challenges in ESI-MS-based Untargeted Metabolomics.
Annotation
Capillary electrophoresis
Liquid chromatography
Mass spectrometry
Metabolomics
Supercritical fluid chromatography
Toxicological and doping analysis
Journal
Chimia
ISSN: 0009-4293
Titre abrégé: Chimia (Aarau)
Pays: Switzerland
ID NLM: 0373152
Informations de publication
Date de publication:
23 Feb 2022
23 Feb 2022
Historique:
received:
26
10
2021
accepted:
14
12
2021
medline:
23
2
2022
pubmed:
23
2
2022
entrez:
9
12
2023
Statut:
epublish
Résumé
Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic changes taking place in biological systems under different conditions. In this article, we aim to provide a short overview of the liquid-phase separation methods hyphenated to MS to perform untargeted metabolomics of biological samples. Each approach is complemented by up-to-date literature to guide readers, as well as practical information for avoiding or fixing some of the most frequently encountered pitfalls. This article covers mainly data acquisition, but a short discussion is provided regarding signal processing and data treatment, as well as data analysis and its biological interpretation in the context of metabolomic studies.
Identifiants
pubmed: 38069754
doi: 10.2533/chimia.2022.90
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-100Informations de copyright
Copyright 2022 Serge Rudaz, Elena Tobolkina, Víctor González-Ruiz, Isabel Meister, Miguel De Figueiredo, Davy Guillarme, Julien Boccard. License: This work is licensed under a Creative Commons Attribution 4.0 International License.