Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative.

activities of daily living amyloid amyloid beta blood blood-based cognition dementia glial fibrillary acidic protein longitudinal neurofilament light chain neuropsychiatric phosphorylated tau protein tau vascular

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
Mar 2024
Historique:
revised: 02 10 2023
received: 29 06 2023
accepted: 29 10 2023
medline: 18 3 2024
pubmed: 18 12 2023
entrez: 18 12 2023
Statut: ppublish

Résumé

We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases. Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ) GFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.

Identifiants

pubmed: 38105605
doi: 10.1002/alz.13560
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
tau Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1753-1770

Subventions

Organisme : CIHR
ID : #163902
Pays : Canada
Organisme : CIHR
ID : #163902
Pays : Canada

Informations de copyright

© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Erlan Sanchez (E)

L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Tim Wilkinson (T)

L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Gillian Coughlan (G)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Saira Mirza (S)

L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Andrée-Ann Baril (AA)

Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.

Joel Ramirez (J)

Dr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Malcolm A Binns (MA)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Sandra E Black (SE)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Dr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Michael Borrie (M)

Lawson Health Research Institute, London, Ontario, Canada.
Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Allison A Dilliott (AA)

Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.

Roger A Dixon (RA)

Department of Psychology, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.

Dar Dowlatshahi (D)

Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Sali Farhan (S)

Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.

Elizabeth Finger (E)

Lawson Health Research Institute, London, Ontario, Canada.
Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Corinne E Fischer (CE)

Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Andrew Frank (A)

Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

Morris Freedman (M)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.

Rafaella A Goncalves (RA)

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.

David A Grimes (DA)

Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Brain and Mind Research Institute, Ottawa, Ontario, Canada.

Ayman Hassan (A)

Thunder Bay Regional Research Institute, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.

Robert A Hegele (RA)

Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Robarts Research Institute, Western University, London, Ontario, Canada.

Sanjeev Kumar (S)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Anthony E Lang (AE)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.

Connie Marras (C)

Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.

Paula M McLaughlin (PM)

Nova Scotia Health, Halifax, Nova Scotia, Canada.
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Joseph B Orange (JB)

School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada.

Stephen H Pasternak (SH)

Department of Clinical Neurological Sciences, Robarts Research Institute, Western University, London, Ontario, Canada.
Parkwood Institute, St. Joseph's Health Care Centre, Western University, London, Ontario, Canada.

Bruce G Pollock (BG)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Tarek K Rajji (TK)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Angela C Roberts (AC)

School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada.

John F Robinson (JF)

Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Robarts Research Institute, Western University, London, Ontario, Canada.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Demetrios J Sahlas (DJ)

McMaster University, Hamilton, Ontario, Canada.

Gustavo Saposnik (G)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stroke Outcomes and Decision Neuroscience Unit, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Michael J Strong (MJ)

Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Canadian Institutes for Health Research, Ottawa, Ontario, Canada.

Richard H Swartz (RH)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

David F Tang-Wai (DF)

Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Krembil Brain Institute Memory Clinic, University Health Network, Toronto, Ontario, Canada.

Maria Carmela Tartaglia (MC)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Krembil Brain Institute Memory Clinic, University Health Network, Toronto, Ontario, Canada.

Angela K Troyer (AK)

Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Neuropsychology and Cognitive Health, Baycrest Health Sciences, Toronto, Ontario, Canada.

Hlin Kvartsberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Henrik Zetterberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Dementia Research Institute, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin, Madison, Wisconsin, USA.

Douglas P Munoz (DP)

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.

Mario Masellis (M)

L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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