Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.

Biological sciences Molecular neuroscience neuroscience

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
19 Jan 2024
Historique:
received: 04 07 2023
revised: 29 10 2023
accepted: 05 12 2023
medline: 29 12 2023
pubmed: 29 12 2023
entrez: 29 12 2023
Statut: epublish

Résumé

Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25

Identifiants

DOI: 10.1016/j.isci.2023.108670 PMID: 38155767 PMC: PMC10753067
pubmed: 38155767
doi: 10.1016/j.isci.2023.108670
pii: S2589-0042(23)02747-5
pmc: PMC10753067
doi:

Types de publication

Journal Article

Langues

eng

Pagination

108670

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: WJG and YW are listed as inventors on the patent “Kit and method for the quantitative detection of steroids” US9851368B2. WJG, EY, YW and ST are shareholders in CholesteniX Ltd.

Auteurs

James Hennegan (J)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

Aled H Bryant (AH)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.

Lauren Griffiths (L)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Oxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.
Multiple Sclerosis Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.

Matthieu Trigano (M)

Dementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.

Oliver J M Bartley (OJM)

Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

Joanna J Bartlett (JJ)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.

Carys Minahan (C)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.

Willy Antoni Abreu de Oliveira (WA)

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.

Eylan Yutuc (E)

Oxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.

Sotirios Ntikas (S)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.

Christos S Bartsocas (CS)

Athens Medical Center, 15125 Athens, Greece.

Margarita Markouri (M)

Athens Medical Center, 15125 Athens, Greece.

Eleni Antoniadou (E)

Athens Medical Center, 15125 Athens, Greece.

Ioanna Laina (I)

Athens Medical Center, 15125 Athens, Greece.

Owain W Howell (OW)

Multiple Sclerosis Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.

Meng Li (M)

Dementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.
Neuroscience and Mental Health Innovation Institute, Cardiff University, Cardiff CF24 4HQ, UK.

Yuqin Wang (Y)

Oxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.

William J Griffiths (WJ)

Oxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.

Emma L Lane (EL)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.

Mariah J Lelos (MJ)

Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

Spyridon Theofilopoulos (S)

Regenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.

Classifications MeSH