Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
received:
02
08
2023
revised:
22
10
2023
accepted:
15
11
2023
medline:
8
1
2024
pubmed:
4
1
2024
entrez:
4
1
2024
Statut:
ppublish
Résumé
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.
Identifiants
pubmed: 38175961
pii: 276477
doi: 10.1084/jem.20231353
pmc: PMC10771097
pii:
doi:
Substances chimiques
Interferon-alpha
0
Interferon Type I
0
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01AI088364
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI160576
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI088364
Pays : United States
Organisme : Medical Research Council
ID : MR/S032304/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI163029
Pays : United States
Organisme : European Research Council
ID : HORIZON-HLTL-2021-ID: 101057100 "Undine"
Pays : International
Organisme : NCATS NIH HHS
ID : UL1TR001866
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Investigateurs
Sergio Aguilera-Albesa
(S)
Suzan A AlKhater
(SA)
Gulsum Alkan
(G)
Riccardo Castagnoli
(R)
Cyril Cyrus
(C)
Sefika Elmas Bozdemir
(S)
Melike Emiroglu
(M)
Belgin Gulhan
(B)
Emine Hafize Erdeniz
(EH)
Nevin Hatipoglu
(N)
Gülsün Iclal Bayhan
(GI)
Petr Jabandziev
(P)
Saliha Kanik Yuksek
(S)
Adem Karbuz
(A)
Şadiye Kübra Tüter Öz
(ŞK)
Gian Luigi Marseglia
(GL)
Ozge Metin Akcan
(O)
Ahmet Osman Kılıç
(AO)
Aslinur Ozkaya Parlakay
(A)
Maria Papadaki
(M)
Katerina Slaba
(K)
Esra Sevketoglu
(E)
Juan Valencia-Ramos
(J)
Aysun Yahşi
(A)
Antonio Aguilera Guirao
(A)
Julián Álvarez Escudero
(J)
Antonio Antela López
(A)
Gema Barbeito Castiñeiras
(G)
Xabier Bello Paderne
(X)
Miriam Ben García
(M)
María Victoria Carral García
(MV)
Miriam Cebey López
(M)
Amparo Coira Nieto
(A)
Mónica Conde Pájaro
(M)
José Javier Costa Alcalde
(JJ)
María José Currás Tuala
(MJ)
Ana Isabel Dacosta Urbieta
(AI)
Blanca Díaz Esteban
(B)
María Jesús Domínguez Santalla
(MJ)
Cristina Fernández Pérez
(C)
Juan Fernández Villaverde
(J)
Cristóbal Galbán Rodríguez
(C)
José Luis García Allut
(JL)
Luisa García Vicente
(L)
Elena Giráldez Vázquez
(E)
Alberto Gómez Carballa
(A)
José Gómez Rial
(J)
Francisco Javier González Barcala
(FJ)
Beatriz Guerra Liñares
(B)
Pilar Leboráns Iglesias
(P)
Beatriz Lence Massa
(B)
Marta Lendoiro Fuentes
(M)
Montserrat López Franco
(M)
Ana López Lago
(A)
Federico Martinón-Torres
(F)
Antonio Salas
(A)
Daniel Navarro De la Cruz
(D)
Eloína Núñez Masid
(E)
Juan Bautista Ortolá Devesa
(JB)
Jacobo Pardo Seco
(J)
María Pazo Núñez
(M)
Marisa Pérez Del Molino Bernal
(M)
Hugo Pérez Freixo
(H)
Lidia Piñeiro Rodríguez
(L)
Sara Pischedda
(S)
Manuel Portela Romero
(M)
Antonio Pose Reino
(A)
Gloria María Prada Hervella
(GM)
Teresa Queiro Verdes
(T)
Lorenzo Redondo Collazo
(L)
Patricia Regueiro Casuso
(P)
Susana Rey García
(S)
Sara Rey Vázquez
(S)
Vanessa Riveiro Blanco
(V)
Irene Rivero Calle
(I)
Carmen Rivero Velasco
(C)
Nuria Rodríguez Núñez
(N)
Carmen Rodríguez-Tenreiro Sánchez
(C)
Eva Saborido Paz
(E)
José Miguel Sadiki Orayyou
(JM)
Carla Saito Villanueva
(C)
Sonia Serén Fernández
(S)
Pablo Souto Sanmartín
(P)
Manuel Taboada Muñiz
(M)
Rocío Trastoy Pena
(R)
Mercedes Treviño Castellano
(M)
Luis Valdés Cuadrado
(L)
Pablo Varela García
(P)
María Soledad Vilas Iglesias
(MS)
Sandra Viz Lasheras
(S)
Rocio Ferreiro-Iglesias
(R)
Iria Bastón-Rey
(I)
Cristina Calviño-Suárez
(C)
Laurent Abel
(L)
Alessandro Aiuti
(A)
Saleh Al-Muhsen
(S)
Fahd Al-Mulla
(F)
Ali Amara
(A)
Mark S Anderson
(MS)
Evangelos Andreakos
(E)
Andrés A Arias
(AA)
Lisa M Arkin
(LM)
Hagit Baris Feldman
(H)
Paul Bastard
(P)
Alexandre Belot
(A)
Catherine M Biggs
(CM)
Dusan Bogunovic
(D)
Alexandre Bolze
(A)
Anastasiia Bondarenko
(A)
Ahmed A Bousfiha
(AA)
Petter Brodin
(P)
Yenan Bryceson
(Y)
Manish J Butte
(MJ)
Jean-Laurent Casanova
(JL)
Giorgio Casari
(G)
John Christodoulou
(J)
Aurélie Cobat
(A)
Roger Colobran
(R)
Antonio Condino-Neto
(A)
Stefan N Constantinescu
(SN)
Megan A Cooper
(MA)
Clifton L Dalgard
(CL)
Murkesh Desai
(M)
Beth A Drolet
(BA)
Xavier Duval
(X)
Jamila El Baghdadi
(J)
Philippine Eloy
(P)
Sara Espinosa-Padilla
(S)
Jacques Fellay
(J)
Carlos Flores
(C)
José Luis Franco
(JL)
Antoine Froidure
(A)
Guy Gorochov
(G)
Peter K Gregersen
(PK)
Bodo Grimbacher
(B)
Filomeen Haerynck
(F)
David Hagin
(D)
Rabih Halwani
(R)
Lennart Hammarström
(L)
James R Heath
(JR)
Elena W Y Hsieh
(EWY)
Eystein Husebye
(E)
Kohsuke Imai
(K)
Yuval Itan
(Y)
Erich D Jarvis
(ED)
Emmanuelle Jouanguy
(E)
Elżbieta Kaja
(E)
Timokratis Karamitros
(T)
Kai Kisand
(K)
Cheng-Lung Ku
(CL)
Yu-Lung Lau
(YL)
Yun Ling
(Y)
Carrie L Lucas
(CL)
Davood Mansouri
(D)
László Maródi
(L)
France Mentré
(F)
Isabelle Meyts
(I)
Joshua D Milner
(JD)
Kristina Mironska
(K)
Trine H Mogensen
(TH)
Tomohiro Morio
(T)
Lisa F P Ng
(LFP)
Luigi D Notarangelo
(LD)
Antonio Novelli
(A)
Giuseppe Novelli
(G)
Cliona O'Farrelly
(C)
Satoshi Okada
(S)
Keisuke Okamoto
(K)
Tayfun Ozcelik
(T)
Qiang Pan-Hammarström
(Q)
Jean W Pape
(JW)
Rebeca Perez de Diego
(R)
Jordi Perez-Tur
(J)
David S Perlin
(DS)
Graziano Pesole
(G)
Anna M Planas
(AM)
Carolina Prando
(C)
Aurora Pujol
(A)
Anne Puel
(A)
Lluis Quintana-Murci
(L)
Sathishkumar Ramaswamy
(S)
Laurent Renia
(L)
Igor Resnick
(I)
Carlos Rodríguez-Gallego
(C)
Vanessa Sancho-Shimizu
(V)
Anna Sediva
(A)
Mikko R J Seppänen
(MRJ)
Mohammed Shahrooei
(M)
Anna Shcherbina
(A)
Ondrej Slaby
(O)
Andrew L Snow
(AL)
Pere Soler-Palacín
(P)
Vassili Soumelis
(V)
András N Spaan
(AN)
Helen C Su
(HC)
Ivan Tancevski
(I)
Stuart G Tangye
(SG)
Ahmad Abou Tayoun
(A)
Şehime Gülsün Temel
(ŞG)
Christian Thorball
(C)
Pierre Tiberghien
(P)
Sophie Trouillet-Assant
(S)
Stuart E Turvey
(SE)
K M Furkan Uddin
(KM)
Mohammed J Uddin
(MJ)
Diederik van de Beek
(D)
Donald C Vinh
(DC)
Horst von Bernuth
(H)
Joost Wauters
(J)
Mayana Zatz
(M)
Pawel Zawadzki
(P)
Qian Zhang
(Q)
Shen-Ying Zhang
(SY)
Informations de copyright
© 2024 Bastard et al.
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