Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media.
collective motion
nanomotors
nanorobots
swarming
viscous media
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
17
10
2023
medline:
18
3
2024
pubmed:
11
1
2024
entrez:
11
1
2024
Statut:
ppublish
Résumé
Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in the joints is mainly composed of hyaluronic acid (HA). These viscous media pose a challenge for many applications in nanomedicine, as passive NPs tend to become trapped in complex networks, which reduces their ability to reach the target location. This problem can be addressed by using active NPs (nanomotors, NMs) that are self-propelled by enzymatic reactions, although the development of enzyme-powered NMs, capable of navigating these viscous environments, remains a considerable challenge. Here, the synergistic effects of two NMs troops, namely hyaluronidase NMs (HyaNMs, Troop 1) and urease NMs (UrNMs, Troop 2) are demonstrated. Troop 1 interacts with the SF by reducing its viscosity, thus allowing Troop 2 to swim more easily through the SF. Through their collective motion, Troop 2 increases the diffusion of macromolecules. These results pave the way for more widespread use of enzyme-powered NMs, e.g., for treating joint injuries and improving therapeutic effectiveness compared with traditional methods.
Identifiants
pubmed: 38200672
doi: 10.1002/smll.202309387
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2309387Subventions
Organisme : Spanish Ministry of Science
ID : PRE2019-088801
Organisme : Beatriu de Pinós Programme
ID : 2021-BP-00079
Organisme : Ministerio de Educación y Formación Profesional
ID : PID2021-128417OB-I00
Organisme : H2020 European Research Council
ID : 866348
Informations de copyright
© 2024 The Authors. Small published by Wiley-VCH GmbH.
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