Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.
AL amyloidosis
Ig-kappa light chain
LC sequence
immunoglobulin light chain
multiple myeloma
Journal
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
ISSN: 1744-2818
Titre abrégé: Amyloid
Pays: England
ID NLM: 9433802
Informations de publication
Date de publication:
11 Jan 2024
11 Jan 2024
Historique:
medline:
11
1
2024
pubmed:
11
1
2024
entrez:
11
1
2024
Statut:
aheadofprint
Résumé
AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM). We analysed cDNA and bulk RNA sequencing of the LCs of AL and MM patients. We studied 41 AL and 83 MM patients showing that This study confirmed that germline usage has an influence on AL amyloidosis risk and organ involvement.
Sections du résumé
BACKGROUND
UNASSIGNED
AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM).
OBJECTIVE
UNASSIGNED
We analysed
MATERIAL AND METHODS
UNASSIGNED
cDNA and bulk RNA sequencing of the LCs of AL and MM patients.
RESULTS
UNASSIGNED
We studied 41 AL and 83 MM patients showing that
CONCLUSION
UNASSIGNED
This study confirmed that germline usage has an influence on AL amyloidosis risk and organ involvement.
Identifiants
pubmed: 38206120
doi: 10.1080/13506129.2023.2295221
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM