Alexandra M Poos

Affiliations

University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany.
CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Publications (18)

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics.

Nature communications

Avec: Stephan M Tirier , Jan-Philipp Mallm , Simon Steiger , Alexandra M Poos , Mohamed H S Awwad , Nicola Giesen , Nicola Casiraghi , Hana Susak , Katharina Bauer , Anja Baumann , Lukas John , Anja Seckinger , Dirk Hose , Carsten Müller-Tidow , Hartmut Goldschmidt , Oliver Stegle , Michael Hundemer , Niels Weinhold , Marc S Raab , Karsten Rippe

A phase 2 clinical trial of combined BRAF/MEK inhibition for BRAFV600E-mutated multiple myeloma.

Blood

Avec: Nicola Giesen , Manik Chatterjee , Christof Scheid , Alexandra M Poos , Britta Besemer , Kaya Miah , Axel Benner , Nicole Becker , Thomas Moehler , Ivana Metzler , Cyrus Khandanpour , Andrea Seidel-Glaetzer , Karolin Trautmann-Grill , K Martin Kortüm , Carsten Müller-Tidow , Gunhild Mechtersheimer , Benjamin Goeppert , Albrecht Stenzinger , Niels Weinhold , Hartmut Goldschmidt , Katja Weisel , Marc S Raab

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach.

BMC bioinformatics

Avec: Alexandra M Poos , Theresa Kordaß , Amol Kolte , Volker Ast , Marcus Oswald , Karsten Rippe , Rainer König

Inhibiting PI3K-AKT-mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells.

Frontiers in oncology

Avec: Luca Heinemann , Klara Maria Möllers , Helal Mohammed Mohammed Ahmed , Lanying Wei , Kaiyan Sun , Subbaiah Chary Nimmagadda , Daria Frank , Anja Baumann , Alexandra M Poos , Martin Dugas , Julian Varghese , Marc-Steffen Raab , Cyrus Khandanpour

Implications and prognostic impact of mass spectrometry in patients with newly-diagnosed multiple myeloma.

Blood cancer journal

Avec: Elias K Mai , Stefanie Huhn , Kaya Miah , Alexandra M Poos , Christof Scheid , Katja C Weisel , Uta Bertsch , Markus Munder , Oscar Berlanga , Dirk Hose , Anja Seckinger , Anna Jauch , Igor W Blau , Mathias Hänel , Hans J Salwender , Axel Benner , Marc S Raab , Hartmut Goldschmidt , Niels Weinhold

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis.

Blood

Avec: Alexandra M Poos , Nina Prokoph , Moritz J Przybilla , Jan-Philipp Mallm , Simon Steiger , Isabelle Seufert , Lukas John , Stephan M Tirier , Katharina Bauer , Anja Baumann , Jennifer Rohleder , Umair Munawar , Leo Rasche , K Martin Kortüm , Nicola Giesen , Philipp Reichert , Stefanie Huhn , Carsten Müller-Tidow , Hartmut Goldschmidt , Oliver Stegle , Marc S Raab , Karsten Rippe , Niels Weinhold

An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma.

Cell death & disease

Avec: Odai Darawshi , Barbara Muz , Shiri Gershon Naamat , Bellam Praveen , Mohamed Mahameed , Karin Goldberg , Priya Dipta , Miriam Shmuel , Francesca Forno , Shatha Boukeileh , Hadas Pahima , Julia Hermann , Marc S Raab , Alexandra M Poos , Niels Weinhold , Chaggai Rosenbluh , Moshe E Gatt , Wilhelm Palm , Abdel Kareem Azab , Boaz Tirosh

Temporal Genomic Dynamics Shape Clinical Trajectory in Multiple Myeloma.

bioRxiv : the preprint server for biology

Avec: Francesco Maura , Marcella Kaddoura , Alexandra M Poos , Linda B Baughn , Bachisio Ziccheddu , Marc-Andrea Bärtsch , Anthony Cirrincione , Kylee Maclachlan , Monika Chojnacka , Benjamin Diamond , Marios Papadimitriou , Patrick Blaney , Lukas John , Philipp Reichert , Stefanie Huhn , Dylan Gagler , Yanming Zhang , Ahmet Dogan , Alexander M Lesokhin , Faith Davies , Hartmut Goldschmidt , Roland Fenk , Katja C Weisel , Elias K Mai , Neha Korde , Gareth J Morgan , S Vincent Rajkumar , Shaji Kumar , Saad Usmani , Ola Landgren , Marc S Raab , Niels Weinhold

Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer.

Molecular oncology

Avec: Doris Höflmayer , Amélie Steinhoff , Claudia Hube-Magg , Martina Kluth , Ronald Simon , Eike Burandt , Maria Christina Tsourlakis , Sarah Minner , Guido Sauter , Franziska Büscheck , Waldemar Wilczak , Stefan Steurer , Hartwig Huland , Markus Graefen , Alexander Haese , Hans Heinzer , Thorsten Schlomm , Frank Jacobsen , Andrea Hinsch , Alexandra M Poos , Marcus Oswald , Karsten Rippe , Rainer König , Cornelia Schroeder

The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma.

Blood

Avec: Anthony M Cirrincione , Alexandra M Poos , Bachisio Ziccheddu , Marcella Kaddoura , Marc-Andrea Baertsch , Kylee H Maclachlan , Monika Chojnacka , Benjamin T Diamond , Lukas John , Philipp Reichert , Stefanie Huhn , Patrick Blaney , Dylan C Gagler , Karsten Rippe , Yanming Zhang , Ahmet Dogan , Alexander M Lesokhin , Faith E Davies , Hartmut Goldschmidt , Roland Fenk , Katja C Weisel , Elias K Mai , Neha Korde , Gareth J Morgan , Saad Z Usmani , Ola Landgren , Marc S Raab , Niels Weinhold , Francesco Maura

Comparison of IGLV2-14 light chain sequences of patients with AL amyloidosis or multiple myeloma.

The FEBS journal

Avec: Natalie Berghaus , Sarah Schreiner , Alexandra M Poos , Marc S Raab , Hartmut Goldschmidt , Elias K Mai , Hans-Jürgen Salwender , Helga Bernhard , Lorenz Thurner , Carsten Müller-Tidow , Niels Weinhold , Ute Hegenbart , Stefan O Schönland , Stefanie Huhn

Genomic Classification and Individualized Prognosis in Multiple Myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: Francesco Maura , Arjun Raj Rajanna , Bachisio Ziccheddu , Alexandra M Poos , Andriy Derkach , Kylee Maclachlan , Michael Durante , Benjamin Diamond , Marios Papadimitriou , Faith Davies , Eileen M Boyle , Brian Walker , Malin Hultcrantz , Ariosto Silva , Oliver Hampton , Jamie K Teer , Erin M Siegel , Niccolò Bolli , Graham H Jackson , Martin Kaiser , Charlotte Pawlyn , Gordon Cook , Dickran Kazandjian , Caleb Stein , Marta Chesi , Leif Bergsagel , Elias K Mai , Hartmut Goldschmidt , Katja C Weisel , Roland Fenk , Marc S Raab , Fritz Van Rhee , Saad Usmani , Kenneth H Shain , Niels Weinhold , Gareth Morgan , Ola Landgren

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks.

Molecular systems biology

Avec: Jan-Philipp Mallm , Murat Iskar , Naveed Ishaque , Lara C Klett , Sabrina J Kugler , Jose M Muino , Vladimir B Teif , Alexandra M Poos , Sebastian Großmann , Fabian Erdel , Daniele Tavernari , Sandra D Koser , Sabrina Schumacher , Benedikt Brors , Rainer König , Daniel Remondini , Martin Vingron , Stephan Stilgenbauer , Peter Lichter , Marc Zapatka , Daniel Mertens , Karsten Rippe

PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power.

Cancers

Avec: Alexandra M Poos , Cornelia Schroeder , Neeraja Jaishankar , Daniela Röll , Marcus Oswald , Jan Meiners , Delia M Braun , Caroline Knotz , Lukas Frank , Manuel Gunkel , Roman Spilger , Thomas Wollmann , Adam Polonski , Georgia Makrypidi-Fraune , Christoph Fraune , Markus Graefen , Inn Chung , Alexander Stenzel , Holger Erfle , Karl Rohr , Aria Baniahmad , Guido Sauter , Karsten Rippe , Ronald Simon , Rainer Koenig

Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Avec: Sarah Schreiner , Natalie Berghaus , Alexandra M Poos , Marc S Raab , Britta Besemer , Roland Fenk , Hartmut Goldschmidt , Elias K Mai , Carsten Müller-Tidow , Niels Weinhold , Ute Hegenbart , Stefanie Huhn , Stefan O Schönland

Characterizing the role of the immune microenvironment in multiple myeloma progression at a single-cell level.

Blood advances

Avec: Carolina Schinke , Alexandra M Poos , Michael Bauer , Lukas John , Sarah Johnson , Shayu Deshpande , Luis Carrillo , Daisy Alapat , Leo Rasche , Sharmilan Thanendrarajan , Maurizio Zangari , Samer Al Hadidi , Frits van Rhee , Faith Davies , Marc S Raab , Gareth Morgan , Niels Weinhold

The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states.

Nature communications

Avec: Leo Rasche , Carolina Schinke , Francesco Maura , Michael A Bauer , Cody Ashby , Shayu Deshpande , Alexandra M Poos , Maurizio Zangari , Sharmilan Thanendrarajan , Faith E Davies , Brian A Walker , Bart Barlogie , Ola Landgren , Gareth J Morgan , Frits van Rhee , Niels Weinhold

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.

Nature communications

Avec: Lukas John , Alexandra M Poos , Alexander Brobeil , Carolina Schinke , Stefanie Huhn , Nina Prokoph , Raphael Lutz , Barbara Wagner , Maurizio Zangari , Stephan M Tirier , Jan-Philipp Mallm , Sabrina Schumacher , Dominik Vonficht , Llorenç Solé-Boldo , Sabine Quick , Simon Steiger , Moritz J Przybilla , Katharina Bauer , Anja Baumann , Stefan Hemmer , Christoph Rehnitz , Christian Lückerath , Christos Sachpekidis , Gunhild Mechtersheimer , Uwe Haberkorn , Antonia Dimitrakopoulou-Strauss , Philipp Reichert , Bart Barlogie , Carsten Müller-Tidow , Hartmut Goldschmidt , Jens Hillengass , Leo Rasche , Simon F Haas , Frits van Rhee , Karsten Rippe , Marc S Raab , Sandra Sauer , Niels Weinhold

Réseau de co-auteurs

Niels Weinhold 13 collaborations

Marc S Raab 12 collaborations

Hartmut Goldschmidt 10 collaborations

Karsten Rippe 8 collaborations

Stefanie Huhn 7 collaborations

Lukas John 6 collaborations

Carsten Müller-Tidow 6 collaborations

Elias K Mai 6 collaborations

Jan-Philipp Mallm 4 collaborations

Anja Baumann 4 collaborations

Katja C Weisel 4 collaborations

Leo Rasche 4 collaborations

Philipp Reichert 4 collaborations

Francesco Maura 4 collaborations

Roland Fenk 4 collaborations

Ola Landgren 4 collaborations

Stephan M Tirier 3 collaborations

Simon Steiger 3 collaborations

Nicola Giesen 3 collaborations

Katharina Bauer 3 collaborations

Marcus Oswald 3 collaborations

Rainer König 3 collaborations

Bachisio Ziccheddu 3 collaborations

Faith Davies 3 collaborations

Gareth J Morgan 3 collaborations

Carolina Schinke 3 collaborations

Maurizio Zangari 3 collaborations

Frits van Rhee 3 collaborations

Anja Seckinger 2 collaborations

Dirk Hose 2 collaborations

Oliver Stegle 2 collaborations

Christof Scheid 2 collaborations

Britta Besemer 2 collaborations

Kaya Miah 2 collaborations

Axel Benner 2 collaborations

Cyrus Khandanpour 2 collaborations

K Martin Kortüm 2 collaborations

Gunhild Mechtersheimer 2 collaborations

Nina Prokoph 2 collaborations

Moritz J Przybilla 2 collaborations

Marcella Kaddoura 2 collaborations

Kylee Maclachlan 2 collaborations

Monika Chojnacka 2 collaborations

Benjamin Diamond 2 collaborations

Marios Papadimitriou 2 collaborations

Patrick Blaney 2 collaborations

Yanming Zhang 2 collaborations

Ahmet Dogan 2 collaborations

Alexander M Lesokhin 2 collaborations

Neha Korde 2 collaborations

Saad Usmani 2 collaborations

Ronald Simon 2 collaborations

Guido Sauter 2 collaborations

Markus Graefen 2 collaborations

Cornelia Schroeder 2 collaborations

Faith E Davies 2 collaborations

Natalie Berghaus 2 collaborations

Sarah Schreiner 2 collaborations

Ute Hegenbart 2 collaborations

Stefan O Schönland 2 collaborations

Gareth Morgan 2 collaborations

Sabrina Schumacher 2 collaborations

Shayu Deshpande 2 collaborations

Sharmilan Thanendrarajan 2 collaborations

Bart Barlogie 2 collaborations

Mohamed H S Awwad 1 collaboration

Nicola Casiraghi 1 collaboration

Hana Susak 1 collaboration

Michael Hundemer 1 collaboration

Manik Chatterjee 1 collaboration

Nicole Becker 1 collaboration

Thomas Moehler 1 collaboration

Ivana Metzler 1 collaboration

Andrea Seidel-Glaetzer 1 collaboration

Karolin Trautmann-Grill 1 collaboration

Benjamin Goeppert 1 collaboration

Albrecht Stenzinger 1 collaboration

Katja Weisel 1 collaboration

Theresa Kordaß 1 collaboration

Amol Kolte 1 collaboration

Volker Ast 1 collaboration

Luca Heinemann 1 collaboration

Klara Maria Möllers 1 collaboration

Helal Mohammed Mohammed Ahmed 1 collaboration

Lanying Wei 1 collaboration

Kaiyan Sun 1 collaboration

Subbaiah Chary Nimmagadda 1 collaboration

Daria Frank 1 collaboration

Martin Dugas 1 collaboration

Julian Varghese 1 collaboration

Marc-Steffen Raab 1 collaboration

Uta Bertsch 1 collaboration

Markus Munder 1 collaboration

Oscar Berlanga 1 collaboration

Anna Jauch 1 collaboration

Igor W Blau 1 collaboration

Mathias Hänel 1 collaboration

Hans J Salwender 1 collaboration

Isabelle Seufert 1 collaboration

Jennifer Rohleder 1 collaboration

Umair Munawar 1 collaboration

Odai Darawshi 1 collaboration

Barbara Muz 1 collaboration

Shiri Gershon Naamat 1 collaboration

Bellam Praveen 1 collaboration

Mohamed Mahameed 1 collaboration

Karin Goldberg 1 collaboration

Priya Dipta 1 collaboration

Miriam Shmuel 1 collaboration

Francesca Forno 1 collaboration

Shatha Boukeileh 1 collaboration

Hadas Pahima 1 collaboration

Julia Hermann 1 collaboration

Chaggai Rosenbluh 1 collaboration

Moshe E Gatt 1 collaboration

Wilhelm Palm 1 collaboration

Abdel Kareem Azab 1 collaboration

Boaz Tirosh 1 collaboration

Linda B Baughn 1 collaboration

Marc-Andrea Bärtsch 1 collaboration

Anthony Cirrincione 1 collaboration

Dylan Gagler 1 collaboration

S Vincent Rajkumar 1 collaboration

Shaji Kumar 1 collaboration

Doris Höflmayer 1 collaboration

Amélie Steinhoff 1 collaboration

Claudia Hube-Magg 1 collaboration

Martina Kluth 1 collaboration

Eike Burandt 1 collaboration

Maria Christina Tsourlakis 1 collaboration

Sarah Minner 1 collaboration

Franziska Büscheck 1 collaboration

Waldemar Wilczak 1 collaboration

Stefan Steurer 1 collaboration

Hartwig Huland 1 collaboration

Alexander Haese 1 collaboration

Hans Heinzer 1 collaboration

Thorsten Schlomm 1 collaboration

Frank Jacobsen 1 collaboration

Andrea Hinsch 1 collaboration

Anthony M Cirrincione 1 collaboration

Marc-Andrea Baertsch 1 collaboration

Kylee H Maclachlan 1 collaboration

Benjamin T Diamond 1 collaboration

Dylan C Gagler 1 collaboration

Saad Z Usmani 1 collaboration

Hans-Jürgen Salwender 1 collaboration

Helga Bernhard 1 collaboration

Lorenz Thurner 1 collaboration

Arjun Raj Rajanna 1 collaboration

Andriy Derkach 1 collaboration

Michael Durante 1 collaboration

Eileen M Boyle 1 collaboration

Brian Walker 1 collaboration

Malin Hultcrantz 1 collaboration

Ariosto Silva 1 collaboration

Oliver Hampton 1 collaboration

Jamie K Teer 1 collaboration

Erin M Siegel 1 collaboration

Niccolò Bolli 1 collaboration

Graham H Jackson 1 collaboration

Martin Kaiser 1 collaboration

Charlotte Pawlyn 1 collaboration

Gordon Cook 1 collaboration

Dickran Kazandjian 1 collaboration

Caleb Stein 1 collaboration

Marta Chesi 1 collaboration

Leif Bergsagel 1 collaboration

Fritz Van Rhee 1 collaboration

Kenneth H Shain 1 collaboration

Murat Iskar 1 collaboration

Naveed Ishaque 1 collaboration

Lara C Klett 1 collaboration

Sabrina J Kugler 1 collaboration

Jose M Muino 1 collaboration

Vladimir B Teif 1 collaboration

Sebastian Großmann 1 collaboration

Fabian Erdel 1 collaboration

Daniele Tavernari 1 collaboration

Sandra D Koser 1 collaboration

Benedikt Brors 1 collaboration

Daniel Remondini 1 collaboration

Martin Vingron 1 collaboration

Stephan Stilgenbauer 1 collaboration

Peter Lichter 1 collaboration

Marc Zapatka 1 collaboration

Daniel Mertens 1 collaboration

Neeraja Jaishankar 1 collaboration

Daniela Röll 1 collaboration

Jan Meiners 1 collaboration

Delia M Braun 1 collaboration

Caroline Knotz 1 collaboration

Lukas Frank 1 collaboration

Manuel Gunkel 1 collaboration

Roman Spilger 1 collaboration

Thomas Wollmann 1 collaboration

Adam Polonski 1 collaboration

Georgia Makrypidi-Fraune 1 collaboration

Christoph Fraune 1 collaboration

Inn Chung 1 collaboration

Alexander Stenzel 1 collaboration

Holger Erfle 1 collaboration

Karl Rohr 1 collaboration

Aria Baniahmad 1 collaboration

Rainer Koenig 1 collaboration

Michael Bauer 1 collaboration

Sarah Johnson 1 collaboration

Luis Carrillo 1 collaboration

Daisy Alapat 1 collaboration

Samer Al Hadidi 1 collaboration

Michael A Bauer 1 collaboration

Cody Ashby 1 collaboration

Brian A Walker 1 collaboration

Alexander Brobeil 1 collaboration

Raphael Lutz 1 collaboration

Barbara Wagner 1 collaboration

Dominik Vonficht 1 collaboration

Llorenç Solé-Boldo 1 collaboration

Sabine Quick 1 collaboration

Stefan Hemmer 1 collaboration

Christoph Rehnitz 1 collaboration

Christian Lückerath 1 collaboration

Christos Sachpekidis 1 collaboration

Uwe Haberkorn 1 collaboration

Antonia Dimitrakopoulou-Strauss 1 collaboration

Jens Hillengass 1 collaboration

Simon F Haas 1 collaboration

Sandra Sauer 1 collaboration