Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells.
5-LOX
COX
Host-pathogen interaction
Hwp1
Leukotriene
Macrophages
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
03
01
2024
received:
29
08
2023
accepted:
04
01
2024
medline:
18
3
2024
pubmed:
18
1
2024
entrez:
17
1
2024
Statut:
ppublish
Résumé
Candida albicans causes opportunistic infections ranging from mucosal mycoses to life-threatening systemic infections in immunocompromised patients. During C. albicans infection, leukotrienes and prostaglandins are formed from arachidonic acid by 5-lipoxygenase (5-LOX) and cyclooxygenases, respectively to amplify inflammatory conditions, but also to initiate macrophage infiltration to achieve tissue homeostasis. Since less is known about the cellular mechanisms triggering such lipid mediator biosynthesis, we investigated the eicosanoid formation in monocyte-derived M1 and M2 macrophages, neutrophils and HEK293 cells transfected with 5-LOX and 5-LOX-activating protein (FLAP) in response to C. albicans yeast or hyphae. Leukotriene biosynthesis was exclusively induced by hyphae in neutrophils and macrophages, whereas prostaglandin E
Identifiants
pubmed: 38233139
doi: 10.1002/eji.202350743
doi:
Substances chimiques
Eicosanoids
0
Leukotrienes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2350743Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 210879364
Organisme : Deutsche Forschungsgemeinschaft
ID : GA-2101/2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : 434385622/GR 5617/1-1
Informations de copyright
© 2024 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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