Sulfated bile acid is a host-derived ligand for MAIT cells.

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
26 Jan 2024
Historique:
medline: 26 1 2024
pubmed: 26 1 2024
entrez: 26 1 2024
Statut: ppublish

Résumé

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize bacterial riboflavin-based metabolites as activating antigens. Although MAIT cells are found in tissues, it is unknown whether any host tissue-derived antigens exist. Here, we report that a sulfated bile acid, cholic acid 7-sulfate (CA7S), binds the nonclassical MHC class I protein MR1 and is recognized by MAIT cells. CA7S is a host-derived metabolite whose levels were reduced by more than 98% in germ-free mice. Deletion of the sulfotransferase 2a family of enzymes (

Identifiants

DOI: 10.1126/sciimmunol.ade6924 PMID: 38277465
pubmed: 38277465
doi: 10.1126/sciimmunol.ade6924
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eade6924

Auteurs

Emi Ito (E)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
ORCID: 0009-0001-0785-0679

Shinsuke Inuki (S)

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto 606-8501, Japan.
ORCID: 0000-0002-7525-1280

Yoshihiro Izumi (Y)

Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan.
ORCID: 0000-0003-4608-4652

Masatomo Takahashi (M)

Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-2493-2684

Yuki Dambayashi (Y)

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Lisa Ciacchi (L)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
ORCID: 0000-0001-9130-7718

Wael Awad (W)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
ORCID: 0000-0002-7597-2133

Ami Takeyama (A)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

Kensuke Shibata (K)

Department of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan.
ORCID: 0000-0001-8794-7368

Shotaro Mori (S)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

Jeffrey Y W Mak (JYW)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0002-8011-4539

David P Fairlie (DP)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0002-7856-8566

Takeshi Bamba (T)

Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-7442-2738

Eri Ishikawa (E)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

Masamichi Nagae (M)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
ORCID: 0000-0002-5470-3807

Jamie Rossjohn (J)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, UK.
ORCID: 0000-0002-2020-7522

Sho Yamasaki (S)

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Osaka, 565-0871, Japan.
ORCID: 0000-0002-5184-6917

Classifications MeSH